Targeting ferroptosis with natural products in liver injury: new insights from molecular mechanisms to targeted therapies

Y Liang, S Qiu, Y Zou, L Luo - Phytomedicine, 2023 - Elsevier
Background Ferroptosis is a brand-new type of controlled cell death that is distinguished by
its reliance on iron and the production of lipid peroxidation. The role of ferroptosis in …

Targeting iron-sulfur clusters in cancer: opportunities and challenges for ferroptosis-based therapy

J Lee, JL Roh - Cancers, 2023 - mdpi.com
Simple Summary Iron-sulfur clusters (ISCs) play a crucial role in cancer cell survival and
growth, and their dysregulation is associated with the development and progression of …

The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

CISD3/MiNT is required for complex I function, mitochondrial integrity, and skeletal muscle maintenance

R Nechushtai, L Rowland, O Karmi… - Proceedings of the …, 2024 - National Acad Sciences
Mitochondria play a central role in muscle metabolism and function. A unique family of iron–
sulfur proteins, termed CDGSH Iron Sulfur Domain-containing (CISD/NEET) proteins …

Relationship between ferroptosis and mitophagy in renal fibrosis: a systematic review

M Zhang, Z Tong, Y Wang, W Fu, Y Meng… - Journal of Drug …, 2023 - Taylor & Francis
Renal fibrosis, characterised by glomerulosclerosis and tubulointerstitial fibrosis, is a typical
pathological alteration in the progression of chronic kidney disease (CKD) to end-stage …

Biochemical and cellular characterization of the CISD3 protein: Molecular bases of cluster release and destabilizing effects of nitric oxide

D Grifagni, JM Silva, L Querci, M Lepoivre… - Journal of Biological …, 2024 - ASBMB
The NEET proteins, an important family of iron-sulfur (Fe-S) proteins, have generated a
strong interest due to their involvement in diverse diseases such as cancer, diabetes, and …

Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

L Zeng, K Yang, G Yu, W Hao, X Zhu, A Ge… - Cell Death & …, 2024 - nature.com
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis
remain unclear. Currently, increasing research has highlighted the role of ferroptosis in …

[HTML][HTML] Ferroptosis in Health and Disease

C Berndt, H Alborzinia, VS Amen, S Ayton, U Barayeu… - Redox Biology, 2024 - Elsevier
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …

STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis

J Zhao, Z Yi, G Deng, Y Li, J Li, M Qin, C Wu… - Free Radical Biology …, 2024 - Elsevier
Abstract The pathogenesis of Autoimmune Hepatitis (AIH) is closely associated with
perturbations in iron ion metabolism, during which Stimulator of Interferon Genes (STING) …

[HTML][HTML] MiR-326 sponges TET2 triggering imbalance of Th17/Treg differentiation to exacerbate pyroptosis of hepatocytes in concanavalin A-induced autoimmune …

G Zhang, S Wu, G Xia - Annals of Hepatology, 2024 - Elsevier
Abstract Introduction and Objectives MicroRNA-326 is abnormally expressed in autoimmune
diseases, but its roles in autoimmune hepatitis (AIH) are unknown. In this study, we aimed to …