Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Background: Mechanical stress on the heart, such as high blood pressure, initiates
inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of …

Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …

Abstract Background Phosphoenolpyruvate Carboxykinase (PCK) has been almost
exclusively recognized as a critical enzyme in gluconeogenesis, especially in liver and …

Exercise plays a central role in the management and treatment of common metabolic
diseases, but modern society presents many barriers to exercise. Over the past decade …

Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

Ethnopharmacological relevance The compound epigallocatechin-3-gallate (EGCG), the
major polyphenolic compound present in green tea [Camellia sinensis (Theaceae], has …

Hypertensive heart disease is a constellation of abnormalities that includes left ventricular
hypertrophy (LVH), systolic and diastolic dysfunction, and their clinical manifestations …

Reactive oxygen species (ROS) have historically been viewed as toxic metabolic byproducts
and causal agents in a myriad of human pathologies. More recent work, however, indicates …