The past decade has witnessed a number of exciting developments in the field of
mitochondrial dynamics–a phenomenon in which changes in mitochondrial shape and …

Background—Cardiomyocytes use Ca2+ not only in excitation-contraction coupling but also
as a signaling molecule promoting, for example, cardiac hypertrophy. It is largely unclear …

Biomechanical stress ie, attributable to pressure overload, leads to cardiac hypertrophy and
may ultimately cause heart failure. Yet, it is still unclear how mechanical stress is sensed …

Sodium butyrate (NaBu) is reported to play important roles in a number of chronic diseases.
The present work is aimed to investigate the effect of NaBu on angiotensin II (Ang II) …

Rationale: Chronic elevation of 3′-5′-cyclic adenosine monophosphate (cAMP) levels
has been associated with cardiac remodeling and cardiac hypertrophy. However …

A wealth of investigations, ranging from clinical and animal model studies to in vitro
analyses, have generated great interest in the cardiovascular effects of leptin. Accordingly …

Heart disease continues to be the leading cause of morbidity and mortality worldwide.
Cardiac malformation during development could lead to embryonic or postnatal death …

Ventricular myocyte hypertrophy is an important compensatory growth response to pressure
overload. However, pathophysiological cardiac hypertrophy is accompanied by reactive …

The adult human heart has an exceptional ability to alter its phenotype to adapt to changes
in environmental demand. This response involves metabolic, mechanical, electrical, and …

Individuals have known that Janus kinase (JAK) signal transducer and activator of
transcription (STAT) signaling pathway was involved in the growth of the cell, cell …