The structural basis of ryanodine receptor ion channel function
G Meissner - Journal of General Physiology, 2017 - rupress.org
Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …
New insights in cardiac calcium handling and excitation-contraction coupling
Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic
output in contractile cells. Several studies have demonstrated that calcium (Ca 2+) plays a …
output in contractile cells. Several studies have demonstrated that calcium (Ca 2+) plays a …
Nitric oxide‐induced calcium release via ryanodine receptors regulates neuronal function
S Kakizawa, T Yamazawa, Y Chen, A Ito… - The EMBO …, 2012 - embopress.org
Mobilization of intracellular Ca2+ stores regulates a multitude of cellular functions, but the
role of intracellular Ca2+ release via the ryanodine receptor (RyR) in the brain remains …
role of intracellular Ca2+ release via the ryanodine receptor (RyR) in the brain remains …
Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity
A Uehara, T Murayama, M Yasukochi, M Fill… - Journal of General …, 2017 - rupress.org
Various ryanodine receptor 2 (RyR2) point mutations cause catecholamine-induced
polymorphic ventricular tachycardia (CPVT), a life-threatening arrhythmia evoked by …
polymorphic ventricular tachycardia (CPVT), a life-threatening arrhythmia evoked by …
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
N Kurebayashi, T Murayama, R Ota, J Suzuki… - Journal of General …, 2022 - rupress.org
Type 2 ryanodine receptor (RYR2) is a cardiac Ca2+ release channel in the ER. Mutations
in RYR2 are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT …
in RYR2 are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT …
Molecular insights into calcium dependent regulation of ryanodine receptor calcium release channels
N Yamaguchi - Calcium Signaling, 2020 - Springer
Ryanodine receptor calcium release channels (RyRs) play central roles in controlling
intracellular calcium concentrations in excitable and non-excitable cells. RyRs are located in …
intracellular calcium concentrations in excitable and non-excitable cells. RyRs are located in …
Two ryanodine receptor isoforms in nonmammalian vertebrate skeletal muscle: Possible roles in excitation–contraction coupling and other processes
T Murayama, N Kurebayashi - Progress in Biophysics and Molecular …, 2011 - Elsevier
The ryanodine receptor (RyR) is a Ca2+ release channel in the sarcoplasmic reticulum in
vertebrate skeletal muscle and plays an important role in excitation–contraction (E–C) …
vertebrate skeletal muscle and plays an important role in excitation–contraction (E–C) …
Two Regions of the Ryanodine Receptor Calcium Channel Are Involved in Ca2+-Dependent Inactivation
AC Gomez, N Yamaguchi - Biochemistry, 2014 - ACS Publications
Skeletal (RyR1) and cardiac muscle (RyR2) isoforms of ryanodine receptor calcium
channels are inhibited by millimollar Ca2+, but the affinity of RyR2 for inhibitory Ca2+ is∼ …
channels are inhibited by millimollar Ca2+, but the affinity of RyR2 for inhibitory Ca2+ is∼ …
Malignant hyperthermia-associated mutations in the S2-S3 cytoplasmic loop of type 1 ryanodine receptor calcium channel impair calcium-dependent inactivation
AC Gomez, TW Holford… - American Journal of …, 2016 - journals.physiology.org
Channel activities of skeletal muscle ryanodine receptor (RyR1) are activated by micromolar
Ca2+ and inactivated by higher (∼ 1 mM) Ca2+. To gain insight into a mechanism …
Ca2+ and inactivated by higher (∼ 1 mM) Ca2+. To gain insight into a mechanism …
Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor
Passive SR (sarcoplasmic reticulum) Ca2+ leak through the RyR (ryanodine receptor) plays
a critical role in the mechanisms that regulate [Ca2+] rest (intracellular resting myoplasmic …
a critical role in the mechanisms that regulate [Ca2+] rest (intracellular resting myoplasmic …