[HTML][HTML] Translational investigation of the therapeutic potential of cannabidiol (CBD): toward a new age
Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a
compound that does not produce the typical subjective effects of marijuana. Objectives: The …
compound that does not produce the typical subjective effects of marijuana. Objectives: The …
[HTML][HTML] Nrf2: An all-rounder in depression
C Zuo, H Cao, Y Song, Z Gu, Y Huang, Y Yang, J Miao… - Redox biology, 2022 - Elsevier
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …
disrupted, it can lead to various pathological outcomes and diseases, such as depression …
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
Major depressive disorder (MDD) is a life‐threatening illness characterized by mood
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …
[HTML][HTML] The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression
X Shu, Y Sun, X Sun, Y Zhou, Y Bian, Z Shu… - Cell death & …, 2019 - nature.com
Although multiple hypotheses had been proposed to clarify the causes of depression, the
accurate pathogenesis and effective treatment of depression still need to be solved …
accurate pathogenesis and effective treatment of depression still need to be solved …
The neurobiology of depression: an integrated overview from biological theories to clinical evidence
Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …
Mitochondria, metabolism, and redox mechanisms in psychiatric disorders
Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …
[HTML][HTML] Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders
Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric
disorders, including anxiety, psychosis, and depression. The mechanisms responsible for …
disorders, including anxiety, psychosis, and depression. The mechanisms responsible for …
[HTML][HTML] Dual role of autophagy in diseases of the central nervous system
T Bar-Yosef, O Damri, G Agam - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Autophagy is a vital lysosomal degradation and recycling pathway in the eukaryotic cell,
responsible for maintaining an intricate balance between cell survival and cell death …
responsible for maintaining an intricate balance between cell survival and cell death …
The shared molecular mechanisms underlying aging of the brain, major depressive disorder, and Alzheimer's disease: The role of circadian rhythm disturbances
An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …
[HTML][HTML] Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 …
P Jiang, Y Guo, R Dang, M Yang, D Liao, H Li… - Journal of …, 2017 - Springer
Background The NLRP3 inflammasome activation and neuroinflammation are known to be
involved in the pathology of depression, whereas autophagy has multiple effects on …
involved in the pathology of depression, whereas autophagy has multiple effects on …