The role of dendritic cells in tissue‐specific autoimmunity

J Mbongue, D Nicholas, A Firek… - Journal of immunology …, 2014 - Wiley Online Library
In this review, we explore the role of dendritic cell subsets in the development of tissue‐
specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is …

[HTML][HTML] Structural aspects of chemical modifications in the MHC-restricted immunopeptidome; Implications for immune recognition

T Sandalova, BM Sala, A Achour - Frontiers in Chemistry, 2022 - frontiersin.org
Significant advances in mass-spectroscopy (MS) have made it possible to investigate the
cellular immunopeptidome, a large collection of MHC-associated epitopes presented on the …

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

JM Ireland, ER Unanue - Journal of Experimental Medicine, 2011 - rupress.org
Antibody responses to citrullinated self-proteins are found in autoimmunities, particularly in
rheumatoid arthritis, where they serve as a diagnostic indicator. We show here that …

[HTML][HTML] A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes

IZ Hartman, AR Kim, RJ Cotter, K Walter, SK Dalai… - Nature medicine, 2010 - nature.com
Immunodominance is defined as restricted responsiveness of T cells to a few selected
epitopes from complex antigens. Strategies currently used for elucidating CD4+ T cell …

[HTML][HTML] The yin/yang balance of the MHC-self-immunopeptidome

L Santambrogio, A Franco - Frontiers in Immunology, 2022 - frontiersin.org
The MHC-self immunopeptidome of professional antigen presenting cells is a cognate
ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T …

Carbamazepine‐Mediated Adverse Drug Reactions: CBZ‐10, 11‐epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA‐B∗ 15: 02

GS Simper, GGT Hò, AA Celik, T Huyton… - Journal of …, 2018 - Wiley Online Library
Among patients treated with the anticonvulsive and psychotropic drug carbamazepine
(CBZ), approximately 10% develop severe and life‐threatening adverse drug reactions …

Spondyloarthritis and smoking: towards a new insight into the disease

D Wendling, C Prati - Expert Review of Clinical Immunology, 2013 - Taylor & Francis
In spondyloarthritis, smoking was found in several studies from the literature to be
associated with earlier onset, more severe disease in activity, function, quality of life and …

[HTML][HTML] Structure of a classical MHC class I molecule that binds “non-classical” ligands

CS Hee, S Gao, B Loll, MM Miller… - PLoS …, 2010 - journals.plos.org
Chicken YF1 genes share a close sequence relationship with classical MHC class I loci but
map outside of the core MHC region. To obtain insights into their function, we determined …

HLA–B27 heavy chains distinguished by a micropolymorphism exhibit differential flexibility

H Fabian, H Huser, B Loll, A Ziegler… - Arthritis & …, 2010 - Wiley Online Library
Objective Although the products of the HLA subtypes B* 2705 and B* 2709 differ only in
residue 116 (Asp versus His) within their peptide‐binding grooves, they are differentially …

[PDF][PDF] Metabolites of C-reactive protein and vimentin are associated with disease activity of axial spondyloarthritis

AS Siebuhr, M Hušaková, S Forejtová… - Clin Exp …, 2019 - clinexprheumatol.org
Objective Non-radiographic (nr-axSpA) and radiographic (AS) forms of axial
spondyloarthritis (axSpA) share clinical features, but have different radiographic patterns …