Serrated polyps have been recognised in the last decade as important premalignant lesions
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …

The term tumour budding denotes that at the invasion front of colorectal adenocarcinomas
tumour cells, singly or in small aggregates, become detached from the neoplastic glands …

OBJECTIVE.: Mutations of BRAF, a downstream mediator of K-RAS, have been described in
serous borderline tumors of the ovary. Data concerning other types of ovarian tumors are …

Mutations in the BRAF serine/threonine kinase gene are frequently found in cutaneous
melanomas. Activation of hypoxia inducible factor-1α (HIF-1α) in response to both hypoxic …

The Wnt and the extracellular signal regulated-kinase (ERK) pathways are both involved in
the pathogenesis of various kinds of cancers. Recently, the existence of crosstalk between …

Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-
associated colorectal carcinoma (CAC). CAC is one of the most important causes of …

Background Current approaches to the detection of colorectal neoplasia associated with
inflammatory bowel disease (IBD‐CRN) are suboptimal. Aim To test the feasibility of using …

Context.—Colorectal cancer, the most lethal long-term complication of chronic inflammatory
bowel disease (IBD), is the culmination of a complex sequence of molecular and histologic …

Inflammatory bowel disease (IBD) is a chronic illness caused by complex interactions
between genetic and environmental factors that propagate inflammation and damage to the …

Over the past 5 years, the Raf kinase family has emerged as a promising target for protein-
directed cancer therapy development. The goal of this review is to first provide a concise …