Epidemiology and pathogenesis of ulcerative colitis

L Du, C Ha - Gastroenterology Clinics, 2020 - gastro.theclinics.com
Ulcerative colitis (UC) is a chronic immune-mediated inflammatory disorder of the colon
(IBD) that is hypothesized to be related to exposure to environmental risk factors leading to …

A comprehensive review and update on the pathogenesis of inflammatory bowel disease

Q Guan - Journal of immunology research, 2019 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic and life‐threating inflammatory disease of
gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis …

Host–microbiota interactions in inflammatory bowel disease

R Caruso, BC Lo, G Núñez - Nature Reviews Immunology, 2020 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

YR Na, M Stakenborg, SH Seok… - … reviews Gastroenterology & …, 2019 - nature.com
Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …

Mechanisms of disease: inflammatory bowel diseases

GP Ramos, KA Papadakis - Mayo Clinic Proceedings, 2019 - Elsevier
Inflammatory bowel diseases (IBDs), represented by Crohn disease and ulcerative colitis,
are associated with major morbidity in Western countries and with increasing incidence in …

[HTML][HTML] The role of monocytes and macrophages in autoimmune diseases: a comprehensive review

WT Ma, F Gao, K Gu, DK Chen - Frontiers in immunology, 2019 - frontiersin.org
Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in …

Y Peng, Y Yan, P Wan, D Chen, Y Ding, L Ran… - Free Radical Biology …, 2019 - Elsevier
In the present study, the therapeutic effects of crude anthocyanins (ACN) from the fruits of
Lycium ruthenicum Murray and the main monomer of ACN, petunidin 3-O-[rhamnopyranosyl …

Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

HC Mirsepasi-Lauridsen, BA Vallance… - Clinical microbiology …, 2019 - Am Soc Microbiol
Gut bacteria play a key role in initiating and maintaining the inflammatory process in the gut
tissues of inflammatory bowel disease (IBD) patients, by supplying antigens or other …

Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases

M Zu, Y Ma, B Cannup, D Xie, Y Jung, J Zhang… - Advanced Drug Delivery …, 2021 - Elsevier
The incidence of inflammatory bowel disease (IBD) is rapidly rising throughout the world.
Although tremendous efforts have been made, limited therapeutics are available for IBD …

[HTML][HTML] Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

RJ Porter, R Kalla, GT Ho - F1000Research, 2020 - ncbi.nlm.nih.gov
Inflammatory bowel diseases are common, complex, immune-mediated conditions with a
sharply rising global prevalence. While major advances since 2000 have provided strong …