ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk
M Sekiguchi, A Sobue, I Kushima, C Wang… - Translational …, 2020 - nature.com
Schizophrenia (SCZ) is known to be a heritable disorder; however, its multifactorial nature
has significantly hampered attempts to establish its pathogenesis. Therefore, in this study …
has significantly hampered attempts to establish its pathogenesis. Therefore, in this study …
Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders
P Penzes, A Buonanno, M Passafaro… - Journal of …, 2013 - Wiley Online Library
Psychiatric and neurodegenerative disorders, including intellectual disability, autism
spectrum disorders (ASD), schizophrenia (SZ), and Alzheimer's disease, pose an immense …
spectrum disorders (ASD), schizophrenia (SZ), and Alzheimer's disease, pose an immense …
BAR domains and membrane curvature: bringing your curves to the BAR.
JL Gallop, HT McMahon - Biochemical Society Symposia, 2005 - portlandpress.com
BAR (bin, amphiphysin and Rvs161/167) domains are a unique class of dimerization
domains, whose dimerization interface is edged by a membrane-binding surface. In its …
domains, whose dimerization interface is edged by a membrane-binding surface. In its …
Kalirin-7 is required for synaptic structure and function
Rho GTPases activated by GDP/GTP exchange factors (GEFs) play key roles in the
developing and adult nervous system. Kalirin-7 (Kal7), the predominant adult splice form of …
developing and adult nervous system. Kalirin-7 (Kal7), the predominant adult splice form of …
Cerebellar development and disease
KJ Millen, JG Gleeson - Current opinion in neurobiology, 2008 - Elsevier
The molecular control of cell-type specification within the developing cerebellum as well as
the genetic causes of the most common human developmental cerebellar disorders have …
the genetic causes of the most common human developmental cerebellar disorders have …
Dendritic spine dynamics–a key role for kalirin-7
P Penzes, KA Jones - Trends in neurosciences, 2008 - cell.com
Changes in the structure and function of dendritic spines contribute to numerous
physiological processes such as synaptic transmission and plasticity, as well as behavior …
physiological processes such as synaptic transmission and plasticity, as well as behavior …
Rho GTPases in intellectual disability: from genetics to therapeutic opportunities
V Zamboni, R Jones, A Umbach, A Ammoni… - International Journal of …, 2018 - mdpi.com
Rho-class small GTPases are implicated in basic cellular processes at nearly all brain
developmental steps, from neurogenesis and migration to axon guidance and synaptic …
developmental steps, from neurogenesis and migration to axon guidance and synaptic …
The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors
Oligophrenin-1 (OPHN1) encodes a Rho-GTPase-activating protein (Rho-GAP) whose loss
of function has been associated with X-linked mental retardation (MR). The …
of function has been associated with X-linked mental retardation (MR). The …
Dysregulation of multiple signaling neurodevelopmental pathways during embryogenesis: a possible cause of autism spectrum disorder
Understanding the autistic brain and the involvement of genetic, non-genetic, and numerous
signaling pathways in the etiology and pathophysiology of autism spectrum disorder (ASD) …
signaling pathways in the etiology and pathophysiology of autism spectrum disorder (ASD) …
Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways
T Saneyoshi, DA Fortin, TR Soderling - Current opinion in neurobiology, 2010 - Elsevier
Formation of the human brain during embryonic and postnatal development is an
extraordinarily complex process resulting at maturity in billions of neurons with trillions of …
extraordinarily complex process resulting at maturity in billions of neurons with trillions of …