The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …

The intricate pathophysiology of brain disorders, difficult access to the brain, and the
complexity and high risks and costs of drug development represent major hurdles for …

Context: Inhaled nanoparticles can migrate to the brain via the olfactory bulb, as
demonstrated in experiments in several animal species. This route of exposure may be the …

The nose is the initial site of viral infection, replication, and transmission in the human body.
Nasally inhaled vaccines may act as a promising alternative for COVID‐19 management in …

The breathing region connects the nasal cavity with the outside environmental air where
flow is accelerated through the nostrils. Particles introduced into the nasal cavity without …

The first book offering a global overview of fundamental microfluidics and the wide range of
possible applications, for example, in chemistry, biology, and biomedical science. As such, it …

Evaluation of nasal spray drug absorption has been challenging because deposited
particles are consistently transported away by mucociliary clearance during diffusing …

Purpose To compare drug deposition in the nose and olfactory region with different nasal
devices and administration techniques. A Sar-Gel based colorimetry method will be …

BACKGROUND: The human respiratory airway undergoes dramatic growth during infancy
and childhood, which induces substantial variability in air flow pattern and particle …

Background: Nose-to-brain (N2B) drug delivery offers unique advantages over intravenous
methods; however, the delivery efficiency to the olfactory region using conventional nasal …