[HTML][HTML] Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates

MS Oliveira, LMG Cassiano, J Pioline… - Journal of …, 2023 - Springer
Introduction Zika virus (ZIKV) caused an outbreak in Brazil, in 2015, being associated to
microcephaly. ZIKV has a strong neurotropism leading to death of infected cells in different …

Update on the animal models and underlying mechanisms for ZIKV-induced microcephaly

D Xu, C Li, CF Qin, Z Xu - Annual review of virology, 2019 - annualreviews.org
The circulation of Zika virus (ZIKV) in nearly 80 countries and territories poses a significant
global threat to public health. ZIKV is causally linked to severe developmental defects in the …

[HTML][HTML] Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study …

J Wongsawat, S Thamthitiwat, VJ Hicks… - PLOS Neglected …, 2024 - journals.plos.org
Background In response to the 2015–2016 Zika virus (ZIKV) outbreak and the causal
relationship established between maternal ZIKV infection and adverse infant outcomes, we …

[HTML][HTML] Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells

P Xu, J Gao, C Shan, TJ Dunn, X Xie… - PLoS neglected …, 2021 - journals.plos.org
Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major
public health concerns. ZIKV has been reported to affect the innate immune responses in …

[HTML][HTML] Using 2D and 3D pluripotent stem cell models to study neurotropic viruses

E LaNoce, J Dumeng-Rodriguez, KM Christian - Frontiers in virology, 2022 - frontiersin.org
Understanding the impact of viral pathogens on the human central nervous system (CNS)
has been challenging due to the lack of viable human CNS models for controlled …

[HTML][HTML] The oxysterol 7-ketocholesterol reduces zika virus titers in vero cells and human neurons

KA Willard, CL Elling, SL Stice, MA Brindley - Viruses, 2018 - mdpi.com
Zika virus (ZIKV) is an emerging flavivirus responsible for a major epidemic in the Americas
beginning in 2015. ZIKV associated with maternal infection can lead to neurological …

Zika virus: Critical crosstalk between pathogenesis, cytopathic effects, and macroautophagy

LC Bernardo‐Menezes, A Agrelli… - Journal of Cellular …, 2023 - Wiley Online Library
Zika virus (ZIKV) is a re‐emerging positive‐sense RNA arbovirus. Its genome encodes a
polyprotein that is cleaved by proteases into three structural proteins (Envelope, pre …

Interplay between Zika virus-induced autophagy and neural stem cell fate determination

Bindu, HS Pandey, P Seth - Molecular Neurobiology, 2023 - Springer
The Zika virus (ZIKV) outbreaks and its co-relation with microcephaly have become a global
health concern. It is primarily transmitted by a mosquito, but can also be transmitted from an …

[HTML][HTML] Route of infection influences Zika virus shedding in a guinea pig model

AE Saver, SA Crawford, JD Joyce, AS Bertke - Cells, 2019 - mdpi.com
Due to the recent epidemic of Zika virus (ZIKV) infection and resulting sequelae, as well as
concerns about both the sexual and vertical transmission of the virus, renewed attention has …

Zika virus is transmitted in neural progenitor cells via cell-to-cell spread, and infection is inhibited by the autophagy inducer trehalose

AE Clark, Z Zhu, F Krach, JN Rich, GW Yeo… - Journal of …, 2021 - Am Soc Microbiol
Zika virus (ZIKV) is a mosquito-borne human pathogen that causes congenital Zika
syndrome and neurological symptoms in some adults. There are currently no approved …