[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs
Cytosolic innate immune sensors are critical for host defense and form complexes, such as
inflammasomes and PANoptosomes, that induce inflammatory cell death. The sensor …
inflammasomes and PANoptosomes, that induce inflammatory cell death. The sensor …
[HTML][HTML] Detection of viral infections by innate immunity
Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …
innate immune system as they detect conserved viral pathogen-associated molecular …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation …
M Moustaqil, E Ollivier, HP Chiu, S Van Tol… - Emerging microbes & …, 2021 - Taylor & Francis
The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and
NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during …
NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during …
Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
NLRP12 downregulates the Wnt/β-catenin pathway via interaction with STK38 to suppress colorectal cancer
S Khan, YT Kwak, L Peng, S Hu… - The Journal of …, 2023 - Am Soc Clin Investig
Colorectal cancer (CRC) at advanced stages is rarely curable, underscoring the importance
of exploring the mechanism of CRC progression and invasion. NOD-like receptor family …
of exploring the mechanism of CRC progression and invasion. NOD-like receptor family …
Distinct and orchestrated functions of RNA sensors in innate immunity
Faithful maintenance of immune homeostasis relies on the capacity of the cellular immune
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …
K63 ubiquitination in immune signaling
C Madiraju, JP Novack, JC Reed, S Matsuzawa - Trends in Immunology, 2022 - cell.com
Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent
evidence has shown that the control of multiple immune functions, including chronic …
evidence has shown that the control of multiple immune functions, including chronic …