[HTML][HTML] Regulation of intestinal barrier function by microbial metabolites

S Ghosh, CS Whitley, B Haribabu, VR Jala - Cellular and molecular …, 2021 - Elsevier
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that
continually shapes host pathophysiological responses. Despite readily available abundant …

The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options

Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …

Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

X Bian, W Wu, L Yang, L Lv, Q Wang, Y Li… - Frontiers in …, 2019 - frontiersin.org
Inflammatory bowel diseases (IBDs) develop as a result of complex interactions among
genes, innate immunity and environmental factors, which are related to the gut microbiota …

Epithelial Toll-like receptors and their role in gut homeostasis and disease

JF Burgueño, MT Abreu - Nature Reviews Gastroenterology & …, 2020 - nature.com
The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced …

X Shao, C Sun, X Tang, X Zhang, D Han… - Journal of Agricultural …, 2020 - ACS Publications
Garlic polysaccharides are great potential agents because of their anti-inflammation,
antioxidation, and immunomodulation properties. However, few studies have reported their …

Chemically induced mouse models of acute and chronic intestinal inflammation

S Wirtz, V Popp, M Kindermann, K Gerlach… - Nature protocols, 2017 - nature.com
Inflammatory bowel diseases (IBDs) result in diarrhea and abdominal pain with further
potential complications such as tissue fibrosis and stenosis. Animal models help in …

Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Z Wang, WH Chen, SX Li, ZM He, WL Zhu, YB Ji… - Molecular …, 2021 - nature.com
Sleep deprivation (SD) is increasingly common in modern society, which can lead to the
dysregulation of inflammatory responses and cognitive impairment, but the mechanisms …

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

P Praveschotinunt, AM Duraj-Thatte, I Gelfat… - Nature …, 2019 - nature.com
Mucosal healing plays a critical role in combatting the effects of inflammatory bowel disease,
fistulae and ulcers. While most treatments for such diseases focus on systemically delivered …

Microbiota-derived metabolite promotes HDAC3 activity in the gut

S Wu, S Hashimoto-Hill, V Woo, EM Eshleman, J Whitt… - Nature, 2020 - nature.com
The coevolution of mammalian hosts and their beneficial commensal microbes has led to
development of symbiotic host–microbiota relationships. Epigenetic machinery permits …

Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in …

Y Peng, Y Yan, P Wan, D Chen, Y Ding, L Ran… - Free Radical Biology …, 2019 - Elsevier
In the present study, the therapeutic effects of crude anthocyanins (ACN) from the fruits of
Lycium ruthenicum Murray and the main monomer of ACN, petunidin 3-O-[rhamnopyranosyl …