Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the
interaction of genetic, environmental, barrier and microbial factors leading to chronic …

Abstract The mucin2 (MUC2) mucus barrier acts as the first barrier that prevents direct
contact between intestinal bacteria and colonic epithelial cells. Bacterial factors related to …

Dysregulated inflammatory responses play a pivotal role in the initiation, development, and
progression of tumors, as demonstrated by the association between ulcerative colitis and the …

Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying
mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to …

Colorectal cancer, the fourth leading cause of cancer-related death worldwide, is a
multifactorial disease involving genetic, environmental and lifestyle risk factors. In addition …

Experimental mouse models are central to basic biomedical research; however, variability
exists across genetically identical mice and mouse facilities making comparisons difficult …

There is increasing recognition of the role the microbiome plays in states of health and
disease. Microbiome studies in systemic autoimmune diseases demonstrate unique …

Egg white peptides (EWPs) can be effectively used to alleviate and treat inflammatory
diseases due to their anti-oxidation, anti-inflammation, and microbiota regulation …

The α7 subtype of the nicotinic acetylcholine receptor (α7 nAChR: coded by Chrna7)
regulates the cholinergic ascending anti-inflammatory pathway involved in depression. We …

The intestine is the shared site of nutrient digestion, microbiota colonization and immune cell
location and this geographic proximity contributes to a large extent to their interaction. The …