MicroRNA and gut microbiota: Tiny but mighty—Novel insights into their cross-talk in inflammatory bowel disease pathogenesis and therapeutics

M Casado-Bedmar, E Viennois - Journal of Crohn's and Colitis, 2022 - academic.oup.com
Abstract MicroRNAs [miRNAs], small non-coding RNAs, have recently been described as
crucial contributors to intestinal homeostasis. They can interact with the gut microbiota in a …

Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases

HQ Tran, RE Ley, AT Gewirtz, B Chassaing - Nature communications, 2019 - nature.com
Alterations in gut microbiota composition are associated with metabolic syndrome and
chronic inflammatory diseases such as inflammatory bowel disease. One feature of …

[HTML][HTML] Oral-gut-brain axis in experimental models of periodontitis: associating gut dysbiosis with neurodegenerative diseases

LD Sansores-España, S Melgar-Rodríguez… - Frontiers in …, 2021 - frontiersin.org
Periodontitis is considered a non-communicable chronic disease caused by a dysbiotic
microbiota, which generates a low-grade systemic inflammation that chronically damages …

Antibiotic-induced microbiome depletion is associated with resilience in mice after chronic social defeat stress

S Wang, Y Qu, L Chang, Y Pu, K Zhang… - Journal of affective …, 2020 - Elsevier
Background The brain–gut axis plays a role in the pathogenesis of stress-related disorders
such as depression. However, the role of brain–gut axis in the resilience versus …

Modified gegen qinlian decoction regulates Treg/Th17 balance to ameliorate DSS-induced acute experimental colitis in mice by altering the gut microbiota

Y Wang, J Zhang, L Xu, J Ma, M Lu, J Ma… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is characterized by chronic pathology associated with
extensive intestinal microbial dysregulation and intestinal inflammation. Thus, efforts are …

[HTML][HTML] Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”

X Hu, Z He, C Zhao, Y He, M Qiu, K Xiang… - Journal of Advanced …, 2024 - Elsevier
Background Mastitis is an inflammatory response in the mammary gland that results in huge
economic losses in the breeding industry. The aetiology of mastitis is complex, and the …

Translating treg therapy for inflammatory bowel disease in humanized mice

S Negi, S Saini, N Tandel, K Sahu, RPN Mishra… - Cells, 2021 - mdpi.com
Crohn's disease and ulcerative colitis, two major forms of inflammatory bowel disease (IBD)
in humans, afflicted in genetically predisposed individuals due to dysregulated immune …

Exploring the microbiome in health and disease: Implications for toxicology

E Scotti, S Boué, GL Sasso, F Zanetti… - Toxicology …, 2017 - journals.sagepub.com
The analysis of human microbiome is an exciting and rapidly expanding field of research. In
the past decade, the biological relevance of the microbiome for human health has become …

Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice

W Li, Y Jia, Z Gong, Z Dong, F Yu, Y Fu, C Jiang… - npj Science of …, 2023 - nature.com
A high-methionine (HM) diet leads to hyperhomocysteinemia (HHcy), while gastrointestinal
tissue is an important site of net homocysteine (Hcy) production. However, the role of the gut …

Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/chronic ulcerative colitis via bidirectionally modulating dysregulated Notch signaling

Y Zhao, H Luan, H Gao, X Wu, Y Zhang, R Li - Phytomedicine, 2020 - Elsevier
Abstract Background Gegen Qinlian decoction (GQ) is a well-known traditional Chinese
medicine that has been clinically proven to be effective in treating ulcerative colitis (UC) …