Customizing cancer treatment at the nanoscale: a focus on anaplastic thyroid cancer therapy

J Wang, J Tan, B Wu, R Wu, Y Han, C Wang… - Journal of …, 2023 - Springer
Anaplastic thyroid cancer (ATC) is a rare but highly aggressive kind of thyroid cancer.
Various therapeutic methods have been considered for the treatment of ATC, but its …

[HTML][HTML] Update on current diagnosis and management of anaplastic thyroid carcinoma

ET Pavlidis, IN Galanis, TE Pavlidis - World Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Well-differentiated thyroid carcinoma has a favorable prognosis with a 5-year survival rate of
over 95%. However, the undifferentiated or anaplastic type accounting for< 0.2%, usually in …

[HTML][HTML] A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers

Y Liu, G Ye, B Dong, L Huang, C Zhang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background Emerging evidence suggests that secreted phosphoprotein 1 (SPP1) is
involved in tumor cell progression in multiple cancer types. However, the role of SPP1 in …

Pan-Genomic Sequencing Reveals Actionable CDKN2A/2B Deletions and Kataegis in Anaplastic Thyroid Carcinoma

A Stenman, M Yang, JO Paulsson, J Zedenius… - Cancers, 2021 - mdpi.com
Simple Summary Anaplastic thyroid carcinoma (ATC) is a tumor with exceedingly high
mortality rates, and current treatment options are very limited once the disease has spread …

GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid …

H Gao, W Wang, Q Li - Cancer biology & therapy, 2022 - Taylor & Francis
Glioma-associated oncogene (Gli) antagonist-61 (GANT61) not only suppresses the
malignant behavior of several cancers but also presents synergistic effects with other …

Poorly differentiated and anaplastic thyroid cancer: Insights into genomics, microenvironment and new drugs

A Prete, A Matrone, C Gambale, L Torregrossa… - Cancers, 2021 - mdpi.com
Simple Summary In the last decades, many researchers produced promising data
concerning genetics and tumor microenvironment of poorly differentiated thyroid cancer …

[HTML][HTML] Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation

JN May, SK Golombek, M Baues, A Dasgupta… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: The blood-brain barrier (BBB) is a major obstacle for drug delivery to the brain.
Sonopermeation, which relies on the combination of ultrasound and microbubbles, has …

Role of m6A RNA methylation in thyroid cancer cell lines

L Allegri, F Baldan, E Molteni, C Mio… - International Journal of …, 2022 - mdpi.com
N6-methyladenosine (m6A) is the most abundant internal modification of RNA in eukaryotic
cells, and, in recent years, it has gained increasing attention. A good amount of data support …

[HTML][HTML] Resveratrol and its nanoparticle suppress doxorubicin/docetaxel-resistant anaplastic thyroid cancer cells in vitro and in vivo

L Xiong, XM Lin, JH Nie, HS Ye, J Liu - Nanotheranostics, 2021 - ncbi.nlm.nih.gov
Background: Docetaxel and doxorubicin combination has been widely used in anaplastic
thyroid cancer/ATC treatment but often results in serious adverse effects and drug …

Modulation of EZH2 activity induces an antitumoral effect and cell redifferentiation in anaplastic thyroid cancer

DC de Mello, KC Saito, MM Cristovão… - International Journal of …, 2023 - mdpi.com
Anaplastic thyroid cancer (ATC) is a rare and lethal form of thyroid cancer that requires
urgent investigation of new molecular targets involved in its aggressive biology. In this …