Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …

[HTML][HTML] Primary prevention of Clostridium difficile infections with a specific probiotic combining Lactobacillus acidophilus, L. ácasei, and L. árhamnosus strains …

LV McFarland, N Ship, J Auclair, M Millette - Journal of Hospital Infection, 2018 - Elsevier
Clostridium difficile infection (CDI) has become the leading healthcare-associated infection
and cause of outbreaks around the world. Although various innovative treatments have been …

Antimicrobial resistance

HD Marston, DM Dixon, JM Knisely, TN Palmore… - Jama, 2016 - jamanetwork.com
Importance The development of antibiotics is considered among the most important
advances of modern science. Antibiotics have saved millions of lives. However …

Clostridium difficile infection increases acute and chronic morbidity and mortality

MA Olsen, D Stwalley, C Demont… - Infection Control & …, 2019 - cambridge.org
ObjectiveIn this study, we aimed to quantify short-and long-term outcomes of Clostridium
difficile infection (CDI) in the elderly, including all-cause mortality, transfer to a facility, and …

Imaging of gastrointestinal tract perforation

D Shin, H Rahimi, S Haroon, A Merritt… - Radiologic …, 2020 - radiologic.theclinics.com
Gastrointestinal (GI) tract perforation involving the stomach, duodenum, small intestine, or
the large bowel occurs as a result of full-thickness GI wall injury with release of intraluminal …

Increasing Age Has Limited Impact on Risk of Clostridium difficile Infection in an Elderly Population

MA Olsen, D Stwalley, C Demont… - Open forum infectious …, 2018 - academic.oup.com
Background Numerous studies have found increased risk of Clostridium difficile infection
(CDI) with increasing age. We hypothesized that increased CDI risk in an elderly population …

Body mass index greater than 35 is associated with severe Clostridium difficile infection

R Mulki, AJ Baumann, T Alnabelsi… - Alimentary …, 2017 - Wiley Online Library
Background Obesity has been implicated in the acquisition of Clostridium difficile infections
(CDI), however, no study has investigated whether there is a correlation between body mass …

High prevalence and genetic diversity of large phiCD211 (phiCDIF1296T)-like prophages in Clostridioides difficile

JR Garneau, O Sekulovic, B Dupuy… - Applied and …, 2018 - Am Soc Microbiol
Clostridioides difficile (formerly Clostridium difficile) is a pathogenic bacterium displaying
great genetic diversity. A significant proportion of this diversity is due to the presence of …

Clostridioides difficile Whole-genome Sequencing Differentiates Relapse With the Same Strain From Reinfection With a New Strain

J Cho, S Cunningham, M Pu, RJ Lennon… - Clinical Infectious …, 2021 - academic.oup.com
Background Current approaches in tracking Clostridioides difficile infection (CDI) and
individualizing patient management are incompletely defined. Methods We recruited 468 …

[HTML][HTML] Incidence, outcome, and risk factors for recurrence of nosocomial Clostridioides difficile infection in adults: a prospective cohort study

WR Karaoui, LBO Rustam, HB Daher… - Journal of Infection and …, 2020 - Elsevier
Abstract Background Nosocomial Clostridioides difficile infection (CDI) complicates up to 1%
of all hospital admissions and is associated with considerable health burden. Aims To …