Mapping the genomic diaspora of gastric cancer
Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
Gastric cancer
E Van Cutsem, X Sagaert, B Topal, K Haustermans… - The Lancet, 2016 - thelancet.com
Gastric cancer is one of the leading causes of cancer-related death worldwide. Many
patients have inoperable disease at diagnosis or have recurrent disease after resection with …
patients have inoperable disease at diagnosis or have recurrent disease after resection with …
[HTML][HTML] Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric …
X Li, Z Sun, G Peng, Y Xiao, J Guo, B Wu, X Li… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: The protumor activities of cancer-associated fibroblasts (CAFs) suggest that
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …
[HTML][HTML] Comparative molecular analysis of gastrointestinal adenocarcinomas
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to
examine shared and distinguishing molecular characteristics of gastrointestinal tract …
examine shared and distinguishing molecular characteristics of gastrointestinal tract …
[HTML][HTML] Comprehensive molecular characterization of gastric adenocarcinoma
Cancer Genome Atlas Research Network - Nature, 2014 - ncbi.nlm.nih.gov
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical
characteristics has been complicated by histological and aetiological heterogeneity. Here …
characteristics has been complicated by histological and aetiological heterogeneity. Here …
Single-cell atlas of lineage states, tumor microenvironment, and subtype-specific expression programs in gastric cancer
V Kumar, K Ramnarayanan, R Sundar… - Cancer discovery, 2022 - AACR
Gastric cancer heterogeneity represents a barrier to disease management. We generated a
comprehensive single-cell atlas of gastric cancer (> 200,000 cells) comprising 48 samples …
comprehensive single-cell atlas of gastric cancer (> 200,000 cells) comprising 48 samples …
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We
aim to establish clinically relevant molecular subtypes that would encompass this …
aim to establish clinically relevant molecular subtypes that would encompass this …
Lapatinib in combination with capecitabine plus oxaliplatin in human epidermal growth factor receptor 2–positive advanced or metastatic gastric, esophageal, or …
JR Hecht, YJ Bang, SK Qin, HC Chung… - Journal of Clinical …, 2016 - ascopubs.org
Purpose To evaluate the efficacy of adding lapatinib to capecitabine and oxaliplatin
(CapeOx) in patients with previously untreated human epidermal growth factor receptor 2 …
(CapeOx) in patients with previously untreated human epidermal growth factor receptor 2 …
Gastric cancer
Gastric cancer is the fifth most common cancer and the third most common cause of cancer
death globally. Risk factors for the condition include Helicobacter pylori infection, age, high …
death globally. Risk factors for the condition include Helicobacter pylori infection, age, high …
[HTML][HTML] Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict.
Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype …
Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype …