Significance: Forces are important in the cardiovascular system, acting as regulators of
vascular physiology and pathology. Residing at the blood vessel interface, cells (endothelial …

Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that
line the blood and lymphatic vessels. The magnitude, pulsatility, and directional …

Rapamycin (Sirolimus®) is used to prevent rejection of transplanted organs and coronary
restenosis. We reported that rapamycin induced cardioprotection against ischemia …

Fluid shear stress plays a key role in sculpting blood vessels during development, in adult
vascular homeostasis and in vascular pathologies. During evolution, endothelial cells …

Significance: Nitric oxide (NO) classical and less classical signaling mechanisms (through
interaction with soluble guanylate cyclase and cytochrome c oxidase, respectively) operate …

Vascular development and maintenance of proper vascular function through various
regulatory mechanisms are critical to our wellbeing. Delineation of the regulatory processes …

Background and aims Transient receptor potential vanilloid type 1 channel (TRPV1) is found
to be expressed in endothelial cells (ECs) and activate endothelial nitric oxide synthase …

Polymers have found widespread applications in cardiology, in particular in coronary
vascular intervention as stent platforms (scaffolds) and coating matrices for drug‐eluting …

Mechanotransduction plays a key role in both normal physiology and in diseases such as
cancer, atherosclerosis and hypertension. Nowhere is this more evident than in the vascular …