The metastasis is the spread of cancer from one part of the body to another. Two‐thirds of
patients with cancer will develop bone metastasis. Breast, prostate and lung cancer are …

Bone is one of the most common sites of cancer metastasis in humans and is a significant
source of morbidity and mortality. Bone metastases are considered incurable and result in …

Metastasis is the leading reason for the resultant mortality of patients with cancer. The past
few decades have witnessed remarkable progress in understanding the molecular and …

Advanced prostate cancer is frequently accompanied by the development of metastasis to
bone. In the past, prostate cancer bone metastases were characterized as being …

BACKGROUND Animal models are important tools to investigate the pathogenesis and
develop treatment strategies for bone metastases in humans. However, there are few …

Prostate cancer is the second leading cause of cancer‐related death in men. A typical
feature of this disease is its ability to metastasize to bone. It is mainly osteosclerotic, and is …

Bone metastases (BoM) are a significant cause of morbidity in patients with estrogen
receptor–positive (ER-positive) breast cancer; yet, characterizations of human specimens …

Prostate cancer frequently metastasizes to bone where it forms osteoblastic lesions through
unknown mechanisms. Bone morphogenetic proteins (BMP) are mediators of skeletal …

The majority of men with progressive prostate cancer develop metastases with the skeleton
being the most prevalent metastatic site. Unlike many other tumors that metastasize to bone …

Hypocalcemia based on serum tCa is a relatively common laboratory abnormality and was
observed in 13.5% of serum biochemical profiles of dogs in one clinical study. 111 Based on …