The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Standardizing workflows in imaging transcriptomics with the abagen toolbox
Gene expression fundamentally shapes the structural and functional architecture of the
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …
Epilepsy and brain network hubs
Epilepsy is a disorder of brain networks. A better understanding of structural and dynamic
network properties may improve epilepsy diagnosis, treatment, and prognostics. Hubs are …
network properties may improve epilepsy diagnosis, treatment, and prognostics. Hubs are …
[HTML][HTML] Comparing spatial null models for brain maps
RD Markello, B Misic - NeuroImage, 2021 - Elsevier
Technological and data sharing advances have led to a proliferation of high-resolution
structural and functional maps of the brain. Modern neuroimaging research increasingly …
structural and functional maps of the brain. Modern neuroimaging research increasingly …
[HTML][HTML] Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?
White matter bundle segmentation using diffusion MRI fiber tractography has become the
method of choice to identify white matter fiber pathways in vivo in human brains. However …
method of choice to identify white matter fiber pathways in vivo in human brains. However …
[HTML][HTML] TractoFlow: A robust, efficient and reproducible diffusion MRI pipeline leveraging Nextflow & Singularity
Diffusion MRI tractography processing pipeline requires a large number of steps (typically
20+ steps). If parameters of these steps, number of threads, and random seed generators …
20+ steps). If parameters of these steps, number of threads, and random seed generators …
Toward personalized medicine in connectomic deep brain stimulation
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …
multitude of neurological and neuropsychiatric disorders. At the single-patient level …
Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia
Connections among brain regions allow pathological perturbations to spread from a single
source region to multiple regions. Patterns of neurodegeneration in multiple diseases …
source region to multiple regions. Patterns of neurodegeneration in multiple diseases …
Prevalence of white matter pathways coming into a single white matter voxel orientation: The bottleneck issue in tractography
Characterizing and understanding the limitations of diffusion MRI fiber tractography is a
prerequisite for methodological advances and innovations which will allow these techniques …
prerequisite for methodological advances and innovations which will allow these techniques …