Introduction Social isolation and lifestyle changes provoked by the COVID-19 pandemic
have negatively affected the level of physical activity of the elderly people. Objective To …

Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or
reclining posture. Evidence relevant to understanding the physiology of SB can be derived …

Sarcopenia is a major component of the frailty syndrome, both being considered as strong
predictors of morbidity, disability, and death in older people. In this review, we explore the …

Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves
both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and …

Changing demographics make it ever more important to understand the modifiable risk
factors for disability and loss of independence with advancing age. For more than two …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Background Frailty is an aging syndrome caused by exceeding a threshold of decline across
multiple organ systems leading to a decreased resistance to stressors. Treatment for frailty …

Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with
increasing age, being a major component in the development of frailty. Current knowledge …

Evolving definitions of frailty, and improved understanding of molecular and physiological
declines in multiple systems that may increase vulnerability in frail, older adults has …

Skeletal muscle mass plays a critical role in a healthy lifespan by helping to regulate
glucose homeostasis. As seen in sarcopenia, decreased skeletal muscle mass impairs …