ATM/ATR Phosphorylation of CtIP on Its Conserved Sae2-like Domain Is Required for Genotoxin-Induced DNA Resection but Dispensable for Animal Development
F Wu-Baer, M Wong, L Tschoe, CS Lin, W Jiang, S Zha… - Cells, 2023 - mdpi.com
Homology-directed repair (HDR) of double-strand DNA breaks (DSBs) is dependent on
enzymatic resection of DNA ends by the Mre11/Rad50/Nbs1 complex. DNA resection is …
enzymatic resection of DNA ends by the Mre11/Rad50/Nbs1 complex. DNA resection is …
RING finger E3 ligase, RNF138 inhibits osteoblast differentiation by negatively regulating Runx2 protein turnover
V Upadhyay, AK Singh, S Sharma… - Journal of Cellular …, 2024 - Wiley Online Library
A few ubiquitin ligases have been shown to target Runx2, the key osteogenic transcription
factor and thereby regulate bone formation. The regulation of Runx2 expression and …
factor and thereby regulate bone formation. The regulation of Runx2 expression and …
Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia
AK Singh, V Upadhyay, A Sethi… - Biochemical …, 2024 - portlandpress.com
E3 ubiquitin ligase, ring finger protein 138 (RNF138) is involved in several biological
processes; however, its role in myeloid differentiation or tumorigenesis remains unclear …
processes; however, its role in myeloid differentiation or tumorigenesis remains unclear …