Immunopathology of chronic hepatitis B infection: role of innate and adaptive immune response in disease progression
A Khanam, JV Chua, S Kottilil - International Journal of Molecular …, 2021 - mdpi.com
More than 250 million people are living with chronic hepatitis B despite the availability of
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …
Immune checkpoints in viral infections
As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate
the function of T-cells via immune checkpoints, it has become increasingly clear that viral …
the function of T-cells via immune checkpoints, it has become increasingly clear that viral …
[HTML][HTML] microRNA-4717 differentially interacts with its polymorphic target in the PD1 3′ untranslated region: A mechanism for regulating PD-1 expression and …
G Zhang, N Li, Z Li, Q Zhu, F Li, C Yang, Q Han, Y Lv… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Programmed cell death-1 (PD-1) is involved in hepatitis B virus (HBV) infection, the
leading cause of hepatocellular carcinoma (HCC) worldwide. Single-nucleotide …
leading cause of hepatocellular carcinoma (HCC) worldwide. Single-nucleotide …
[HTML][HTML] Immune checkpoints on T and NK cells in the context of HBV infection: Landscape, pathophysiology and therapeutic exploitation
In hepatitis B virus (HBV) infection, the interplay between the virus and the host immune
system is crucial in determining the pathogenesis of the disease. Patients who fail to mount …
system is crucial in determining the pathogenesis of the disease. Patients who fail to mount …
Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis …
F Li, N Li, J Sang, X Fan, H Deng, X Zhang… - Cancer management …, 2018 - Taylor & Francis
Background and objective Upregulated T-cell immunoglobulin and mucin domain
containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8+ T-cells contributes to …
containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8+ T-cells contributes to …
[HTML][HTML] Restoring homeostasis of CD4+ T cells in hepatitis-B-virus-related liver fibrosis
LS Cheng, Y Liu, W Jiang - World Journal of Gastroenterology …, 2015 - ncbi.nlm.nih.gov
Immune-mediated liver injury is widely seen during hepatitis B virus (HBV) infection.
Unsuccessful immune clearance of HBV results in chronic hepatitis and increases the risk of …
Unsuccessful immune clearance of HBV results in chronic hepatitis and increases the risk of …
[HTML][HTML] The advantages of PD1 activating chimeric receptor (PD1-ACR) engineered lymphocytes for PDL1+ cancer therapy
X Tang, Q Li, Y Zhu, D Zheng, J Dai, W Ni… - American journal of …, 2015 - ncbi.nlm.nih.gov
Tumors exploit immunoregulatory checkpoints to attenuate T cell responses as a means of
circumventing immunologic rejection. By activating the inhibitory costimulatory pathway of …
circumventing immunologic rejection. By activating the inhibitory costimulatory pathway of …
The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection
Patients with chronic hepatitis B (CHB) gradually develop T cell exhaustion, and the
inhibitory receptor molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), may play a role in …
inhibitory receptor molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), may play a role in …
Regulation of HBV-specific CD8+ T cell-mediated inflammation is diversified in different clinical presentations of HBV infection
CM Dinney, LD Zhao, CD Conrad, JM Duker… - journal of …, 2015 - Springer
Chronic HBV infection is the leading cause of liver cirrhosis and hepatic cancer, but the
individual responses toward HBV infection are highly variable, ranging from asymptomatic to …
individual responses toward HBV infection are highly variable, ranging from asymptomatic to …
Type I interferon elevates co-regulatory receptor expression on CMV-and EBV-specific CD8 T cells in chronic hepatitis C
Hepatitis C virus (HCV) readily sets up persistence in a large fraction of infected hosts.
Mounting epidemiological and immunological evidence suggest that HCV's persistence …
Mounting epidemiological and immunological evidence suggest that HCV's persistence …