Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …

The ubiquitin-proteasome system (UPS) is a fundamental regulatory mechanism in cells,
vital for maintaining cellular homeostasis, compiling signaling transduction, and determining …

Cancer is one of the most common and widely diagnosed diseases worldwide. With an
increase in prevalence and incidence, many studies in cancer biology have been looking at …

Abstract CBLC (CBL proto-oncogene C) is an E3 ubiquitin protein ligase that plays a key
role in cancers. However, the function and mechanism of CBLC in colorectal cancer (CRC) …

Objectives: This study combines two innovative mouse models in a major gene discovery
project to assess the influence of host genetics on asbestos related disease (ARD) …

Non‐small‐cell lung cancer (NSCLC) is the most common lung cancer and a major cause of
cancer mortality worldwide. Deguelin plays a vital inhibitory role in NSCLC initiation and …

Breast and ovarian cancers are prevalent worldwide, with genetic factors such as BRCA1
and BRCA2 mutations playing a significant role. However, not all patients carry these …

Cholangiocarcinoma (CCA) is a highly malignant disease with a poor prognosis, and
mechanisms of initiation and development are not well characterized. It is long noncoding …

E3 ubiquitin ligases are a class of enzymes, essential for maintaining the equilibrium of cells
by binding ubiquitin molecules to substrates to mark them for destruction. Since many …

Background: Cholangiocarcinoma (CCA) is a highly malignant disease with poor prognosis.
Its occurrence and development mechanisms remain unearthed. The ceRNA network …