Atherosclerotic coronary artery disease (CAD) results from build-up of cholesterol-rich
plaques in the walls of the coronary arteries and is a leading cause of death. Inflammation is …

Background Low-density lipoprotein cholesterol (LDL-C) causes atherosclerotic disease, as
demonstrated in experimental and epidemiological cohorts, randomised controlled trials …

An increased risk of cardiovascular disease, independent of conventional risk factors, is
present even at minor levels of renal impairment and is highest in patients with end-stage …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Background Global prescription drug use has been increasing continuously for decades.
The gut microbiome, a key contributor to health status, can be altered by prescription drug …

Background: There is considerable interest in whether genetic data can be used to improve
standard cardiovascular disease risk calculators, as the latter are routinely used in clinical …

The first randomized controlled data from cardiovascular outcomes trials with proprotein
convertase subtilisin/kexin type 9 (PCSK9) inhibitors have now been reported. 1, 2 This …

Statins are a cornerstone in the pharmacological prevention of cardiovascular disease.
Although generally well tolerated, a small subset of patients experience statin-related …

Importance The association between statin-induced reduction in low-density lipoprotein
cholesterol (LDL-C) levels and the absolute risk reduction of individual, rather than …

Elevated levels of low-density lipoprotein cholesterol (LDL-C) are associated with increased
risk of coronary heart disease and stroke. Guidelines for the management of dyslipidaemia …