Cancer cachexia is an unmet clinical need that affects more than 50% of patients with
cancer. The systemic inflammatory response, which is mediated by a network of cytokines …

Resistin, a small secretory molecule, has been implicated to play an important role in the
development of insulin resistance under obese condition. For the past few decades, it has …

Leptin is a nutritional cytokine, and it is closely related to the progression of cancer.
However, the detailed effect of leptin in lung cancer remains poorly known. We found leptin …

Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which
is due to delayed diagnosis and resistance to current therapies. The interactions between …

Cancer cachexia is a disorder of energy balance characterized by the wasting of adipose
tissue and skeletal muscle resulting in severe weight loss with profound influence on …

A tumor extends its effects beyond its local site, and one such effect is cancer cachexia
which is caused by a state of systemic inflammation in response to cancer. Though the …

Excess body weight and obesity have become significant risk factors for cancer
development. During obesity, adipose tissue alters its biological function, deregulating the …

In response to obesity-associated chronic inflammatory disorders, adipose tissue releases a
biologically active peptide known as leptin. Leptin activates the secretion of chemical …

Resistin is an adipokine that is associated with obesity, inflammation, and various cancers.
Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. VEGF-A …

The family of resistin-like molecules (RELMs) consists of four members in rodents
(RELMα/FIZZ1/HIMF, RELMβ/FIZZ2, Resistin/FIZZ3, and RELMγ/FIZZ4) and two members in …