Immune cells rely on cell-cell communication to specify and fine-tune their responses. They
express an extensive network of cell communication modes, including a vast repertoire of …

The innervation of bone has been described for centuries, and our understanding of its
function has rapidly evolved over the past several decades to encompass roles of subtype …

The timely secretion of gonadal sex steroids is essential for the initiation of puberty, the
postpubertal maintenance of secondary sexual characteristics and the normal perinatal …

The neurokinin 1 receptor (NK‐1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is …

OBJECTIVE: To investigate the presence of neurokinin B (NKB)/NK3 receptor (NK3R) and
kisspeptin/KISS1 receptor (KISS1R) messenger RNA (mRNA) and proteins throughout the …

Heterotopic ossification (HO) is a disabling condition associated with neurologic injury,
inflammation, and overactive bone morphogenetic protein (BMP) signaling. The inductive …

Tachykinins (TKs) constitute the largest vertebrate brain/gut peptide family. Since discovery
of Substance P as a structurally unidentified vasodilatory and contractile compound in 1931 …

Highly sophisticated and synchronized interactions of various cells and hormonal signals
are required to make organisms competent for reproduction. GnRH neurons act as a …

Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive
functions, recent data described its action in the control of metabolism. Of particular interest …

Patients bearing mutations in TAC3 and TACR3 (which encode neurokinin B and its
receptor, respectively) have sexual infantilism and infertility due to GnRH deficiency. In …