Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters
Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development
Cholesterol homeostasis is impaired in Alzheimer's disease; however, attempts to modulate
brain cholesterol biology have not translated into tangible clinical benefits for patients to …
brain cholesterol biology have not translated into tangible clinical benefits for patients to …
The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond
Abstract Multidrug resistance protein 7 (MRP7), also known as ATP-binding cassette (ABC)
transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001 …
transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001 …
Identification and expression analysis of ATP-binding cassette (ABC) transporters revealed its role in regulating stress response in pear (Pyrus bretchneideri)
X Kou, Z Zhao, X Xu, C Li, J Wu, S Zhang - BMC genomics, 2024 - Springer
Background ATP-binding cassette (ABC) transporter proteins constitute a plant gene
superfamily crucial for growth, development, and responses to environmental stresses …
superfamily crucial for growth, development, and responses to environmental stresses …
Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy
KKW To, Z Huang, H Zhang, CR Ashby Jr, L Fu - Drug Resistance Updates, 2024 - Elsevier
Multidrug resistance (MDR) is one of the primary factors that produces treatment failure in
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …
Structure, function, and inhibition of catalytically asymmetric ABC transporters: lessons from the PDR subfamily
A Banerjee, J Pata, V Chaptal, A Boumendjel… - Drug Resistance …, 2023 - Elsevier
ATP-binding cassette (ABC) superfamily comprises a large group of ubiquitous
transmembrane proteins that play a crucial role in transporting a diverse spectrum of …
transmembrane proteins that play a crucial role in transporting a diverse spectrum of …
Cadmium transport by mammalian ATP-binding cassette transporters
F Thévenod, WK Lee - Biometals, 2024 - Springer
Cellular responses to toxic metals depend on metal accessibility to intracellular targets,
reaching interaction sites, and the intracellular metal concentration, which is mainly …
reaching interaction sites, and the intracellular metal concentration, which is mainly …
Deciphering treatment resistance in metastatic colorectal cancer: roles of drug transports, EGFR mutations, and HGF/c-MET signaling
N Albadari, Y Xie, W Li - Frontiers in Pharmacology, 2024 - frontiersin.org
In 2023, colorectal cancer (CRC) is the third most diagnosed malignancy and the third
leading cause of cancer death worldwide. At the time of the initial visit, 20% of patients …
leading cause of cancer death worldwide. At the time of the initial visit, 20% of patients …
Emerging role of ABC transporters in glia cells in health and diseases of the central nervous system
M Villa, J Wu, S Hansen, J Pahnke - Cells, 2024 - mdpi.com
ATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of
substrates across different cellular membranes. In the central nervous system (CNS), ABC …
substrates across different cellular membranes. In the central nervous system (CNS), ABC …
Nano-enabled strategies for the treatment of lung cancer: potential bottlenecks and future perspectives
MK Alshammari, EY Almomen, KF Alshahrani… - Biomedicines, 2023 - mdpi.com
On a global scale, lung cancer is acknowledged to be the major driver of cancer death
attributable to treatment challenges and poor prognosis. Classical cancer treatment …
attributable to treatment challenges and poor prognosis. Classical cancer treatment …