The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases

HM Blevins, Y Xu, S Biby, S Zhang - Frontiers in aging neuroscience, 2022 - frontiersin.org
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Health benefits of quercetin in age-related diseases

Deepika, PK Maurya - Molecules, 2022 - mdpi.com
Polyphenols are the known group of phytochemicals that essentially consists of phenolic
rings. These are the plant product present in varied fruits and vegetables. These secondary …

Wound healing: cellular mechanisms and pathological outcomes

HN Wilkinson, MJ Hardman - Open biology, 2020 - royalsocietypublishing.org
Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

Quercetin: its main pharmacological activity and potential application in clinical medicine

D Yang, T Wang, M Long, P Li - Oxidative Medicine and …, 2020 - Wiley Online Library
Quercetin is a flavonoid compound widely present in plants and exhibits a variety of
biological activities. Research on quercetin has shown its potential for medical application …

Quercetin and metabolic syndrome: A review

A Hosseini, BM Razavi, M Banach… - Phytotherapy …, 2021 - Wiley Online Library
Metabolic syndrome (MetS) is a complex of diseases that lead to mortality due to the
development of cardiovascular problems. Quercetin, as an important flavonoid, has various …

Therapeutic potential of quercetin: new insights and perspectives for human health

B Salehi, L Machin, L Monzote, J Sharifi-Rad… - ACS …, 2020 - ACS Publications
Quercetin (Que) and its derivatives are naturally occurring phytochemicals with promising
bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti …

Polyphenols: A concise overview on the chemistry, occurrence, and human health

A Durazzo, M Lucarini, EB Souto, C Cicala… - Phytotherapy …, 2019 - Wiley Online Library
This review gives an updated picture of each class of phenolic compounds and their
properties. The most common classification implies the subdivision of phenolics in two main …

Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential

F Madeo, D Carmona-Gutierrez, SJ Hofer, G Kroemer - Cell metabolism, 2019 - cell.com
The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …

Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus

J Blahova, M Martiniakova, M Babikova, V Kovacova… - Pharmaceuticals, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is the most widespread form of diabetes, characterized by
chronic hyperglycaemia, insulin resistance, and inefficient insulin secretion and action …

Anti-obesity effects of polyphenol intake: Current status and future possibilities

M Boccellino, S D'Angelo - International journal of molecular sciences, 2020 - mdpi.com
The prevalence of obesity has steadily increased worldwide over the past three decades.
The conventional approaches to prevent or treat this syndrome and its associated …