[HTML][HTML] Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease

WB Limpitikul, S Das - Journal of Cardiovascular Development and …, 2023 - mdpi.com
Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with
increased morbidity and mortality. The mechanisms underlying AF are complex and …

[HTML][HTML] TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation

Y Wu, S Zhan, L Chen, M Sun, M Li, X Mou… - Journal of Translational …, 2023 - Springer
Background Tumour necrosis factor superfamily protein 14 (TNFSF14), also called LIGHT, is
an important regulator of immunological and fibrosis diseases. However, its specific …

Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation

AE Lin, AC Bapat, L Xiao, A Niroula, J Ye, WJ Wong… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), a common age-
associated phenomenon, associates with increased risk of both hematological malignancy …

SGK1 is involved in doxorubicin-induced chronic cardiotoxicity and dysfunction through activation of the NFκB pathway

Y Zhang, D Zhang, T Meng, P Tian, J Chen… - International …, 2023 - Elsevier
Breast cancer is the predominant cancer among women worldwide, and chemotherapeutic
agents, such as doxorubicin (DOX), have the potential to significantly prolong survival, albeit …

The role of serum/glucocorticoid-regulated kinase 1 in brain function following cerebral ischemia

CYC Wu, Y Zhang, L Xu, Z Huang… - Journal of Cerebral …, 2024 - journals.sagepub.com
Cardiopulmonary arrest (CA) is a major cause of death/disability in the US with poor
prognosis and survival rates. Current therapeutic challenges are physiologically complex …

[HTML][HTML] Overview of programmed electrical stimulation to assess atrial fibrillation susceptibility in mice

MB Murphy, PJ Kannankeril, KT Murray - Frontiers in Physiology, 2023 - frontiersin.org
Atrial fibrillation (AF) is the most common human arrhythmia and is associated with
increased risk of stroke, dementia, heart failure, and death. Among several animal models …

[HTML][HTML] Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel …

M Šimon, Š Mikec, SS Atanur, J Konc, NM Morton… - Genes & genomics, 2024 - Springer
Background Analysing genomes of animal model organisms is widely used for
understanding the genetic basis of complex traits and diseases, such as obesity, for which …

Metabolomics and Biomarkers for Paroxysmal and Persistent Atrial Fibrillation

LL Zhang, WH Lin, CY Di, HT Hou… - Journal of the …, 2024 - Am Heart Assoc
Background Atrial fibrillation (AF) is the most common type of arrhythmia worldwide and is
associated with serious complications. This study investigated the metabolic biomarkers …

Experimental models and model organisms in cardiac electrophysiology: Opportunities and challenges

R Coronel, IR Efimov, F Vaillant, C Jopling, Y Etzion… - 2023 - books.google.com
QT interval measurement is an important aspect of any ECG evaluation and interpretation. It
has significant clinical importance, as there is a correlation between the QT interval value …