Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy

C Alix-Panabières, K Pantel - Cancer discovery, 2016 - AACR
Abstract “Liquid biopsy” focusing on the analysis of circulating tumor cells (CTC) and
circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received …

Bone metastasis and the metastatic niche

G Ren, M Esposito, Y Kang - Journal of molecular medicine, 2015 - Springer
The bone marrow has been long known to host a unique environment amenable to
colonization by metastasizing tumor cells. Yet, the underlying molecular interactions within …

Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity

A Gröbe, M Blessmann, H Hanken, RE Friedrich… - Clinical Cancer …, 2014 - AACR
Purpose: Current staging methods for squamous cell carcinomas (SCC) of the oral cavity
(OSCC) need to be improved to predict the risk of individual patients. Because …

[HTML][HTML] Bone marrow as a reservoir for disseminated tumor cells: a special source for liquid biopsy in cancer patients

K Pantel, C Alix-Panabières - BoneKEy reports, 2014 - ncbi.nlm.nih.gov
Besides circulating tumor cells, disseminated tumor cells (DTCs) in bone marrow (BM) might
be used as a 'liquid biopsy'to obtain information helpful to steer therapies in individual …

Circulating tumor cells as a biomarker for preoperative prognostic staging in patients with esophageal cancer

M Reeh, KE Effenberger, AM Koenig… - Annals of …, 2015 - journals.lww.com
Objective: We evaluated the prognostic significance of circulating tumor cells (CTCs) in
patients with esophageal cancer (EC). Background: Despite the availability of several …

Exploiting bone niches: progression of disseminated tumor cells to metastasis

AM Muscarella, S Aguirre, X Hao… - The Journal of …, 2021 - Am Soc Clin Investig
Many solid cancers metastasize to the bone and bone marrow (BM). This process may occur
even before the diagnosis of primary tumors, as evidenced by the discovery of disseminated …

Diagnostic methods for detection of bone metastases

B Łukaszewski, J Nazar, M Goch… - Contemporary …, 2017 - termedia.pl
Skeletal metastases are severe complications in the course of cancer, and they indicate a
worse prognosis. The use of modern imaging techniques allows rapid diagnosis of bone …

Disseminated tumour cells in bone marrow are the source of cancer relapse after therapy

B Sai, J Xiang - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Accumulating evidence indicates that cancer cells spread much earlier than was previously
believed. Recent technological advances have greatly improved the detection methods of …

Molecular characterization of circulating tumor cells—from bench to bedside

Y Li, S Wu, F Bai - Seminars in Cell & Developmental Biology, 2018 - Elsevier
Circulating tumor cells (CTCs) are cancer cells discovered in cancer patients' peripheral
blood that successfully escape from the primary tumor site and/or metastases, struggle to …

Liquid biopsy: A new avenue in pathology

RK Ghosh, T Pandey, P Dey - Cytopathology, 2019 - Wiley Online Library
Liquid biopsy is a relatively new entity. This non‐invasive technique provides real‐time
information about a tumour. The liquid biopsy contains circulating tumour cells, cell‐free …