Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …

Quinoline analogs are an important class of N-based heterocyclic compounds, which have
received extensive attention because of their use in medicinal chemistry and organic …

A series of previously synthesized conjugates of tacrine and salicylamide was extended by
varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize …

We synthesized eleven new amiridine-piperazine hybrids 5a-j and 7 as potential
multifunctional agents for Alzheimer's disease (AD) treatment by reacting N …

Due to the hugely important roles of neurotransmitter acetylcholine (ACh) and amyloid-β
(Aβ) in the pathogenesis of Alzheimer's disease (AD), the development of multi-target …

To develop novel antimicrobial agents, and based on the biologically active heterocyclic
quinoline and thiazole substituted, a series of novel α-aminophosphonates (9a–h) and (10i …

New hybrids of 4-amino-2, 3-polymethylenequinoline with different sizes of the aliphatic ring
linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers …

Permeation through the blood–brain barrier (BBB) is among the most important processes
controlling the pharmacokinetic properties of drugs and other bioactive compounds. Using …

A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds
of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized …

The design and development of effective multitargeted agents in treating Alzheimer disease
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …