Circuit dysfunction models of psychiatric disease posit that pathological behavior results
from abnormal patterns of electrical activity in specific cells and circuits in the brain. Many …

Vulnerability to drug abuse is related to both reward seeking and impulsivity, two constructs
thought to have a biological basis in the prefrontal cortex (PFC). This review addresses …

The evidence for the involvement of the serotonergic system in the pathogenesis of
obsessive-compulsive disorder (OCD) is circumstantial at best, despite being the focus for …

During the last 30 years there have been many attempts to develop animal models of
obsessive-compulsive disorder (OCD). Most models have not been studied further following …

Compulsive behaviors have been associated with striatal hyperactivity. Parvalbumin-
positive striatal interneurons (PVIs) in the striatum play a crucial role in regulating striatal …

During the last 30 years there have been many attempts to develop animal models of
obsessive compulsive disorder (OCD), in the hope that they may provide a route for …

In simple reaction time tasks, lesions of rat dorsomedial prefrontal cortex impair the ability to
wait for trigger stimuli and result in increased premature responding. This effect could be …

During the last 30 years there have been many attempts to develop animal models of
obsessive compulsive disorder (OCD), in the hope that they may provide a route for …

Animal models have proved extremely useful in assisting researchers to better understand a
given clinical disorder. The difficulty in developing a suitable animal model lies in whether it …

Animal models in the field of addiction are considered to be among the best available
models of neuropsychiatric disease. These models have undergone a number of …