[HTML][HTML] The role of MSC in wound healing, scarring and regeneration
R Guillamat-Prats - Cells, 2021 - mdpi.com
Tissue repair and regeneration after damage is not completely understood, and current
therapies to support this process are limited. The wound healing process is associated with …
therapies to support this process are limited. The wound healing process is associated with …
[HTML][HTML] Exploring animal models that resemble idiopathic pulmonary fibrosis
J Tashiro, GA Rubio, AH Limper, K Williams… - Frontiers in …, 2017 - frontiersin.org
Large multicenter clinical trials have led to two recently approved drugs for patients with
idiopathic pulmonary fibrosis (IPF); yet, both of these therapies only slow disease …
idiopathic pulmonary fibrosis (IPF); yet, both of these therapies only slow disease …
[HTML][HTML] MSC based therapies—new perspectives for the injured lung
J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …
The potential of mesenchymal stem cell therapy for chronic lung disease
Introduction: Mesenchymal stem/stromal cells (MSCs) have been shown to improve lung
function and survival in chronic inflammatory lung diseases, including asthma, chronic …
function and survival in chronic inflammatory lung diseases, including asthma, chronic …
[HTML][HTML] Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes
Mesenchymal stromal/stem cell (MSC) therapy has shown promise in experimental models
of idiopathic pulmonary fibrosis (IPF). The aim of this study was to test the therapeutic effects …
of idiopathic pulmonary fibrosis (IPF). The aim of this study was to test the therapeutic effects …
Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk
Idiopathic pulmonary fibrosis (IPF) is characterized by devastating and progressive lung
parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of …
parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of …
[HTML][HTML] Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies
Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …
[HTML][HTML] A role for extracellular vesicles in SARS-CoV-2 therapeutics and prevention
Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and
microvesicles serving dominant roles in intercellular communication. Both viable and dying …
microvesicles serving dominant roles in intercellular communication. Both viable and dying …
[HTML][HTML] Mesenchymal stem cells for the treatment of idiopathic pulmonary fibrosis
A Tzouvelekis, R Toonkel, T Karampitsakos… - Frontiers in …, 2018 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is an inexorably progressive lung disease of unknown
origin. Prognosis is poor, with limited treatment options available, and the median survival …
origin. Prognosis is poor, with limited treatment options available, and the median survival …
Inhibition of aberrant tissue remodelling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues
The precise understanding and control of microenvironmental cues could be used to
optimize the efficacy of cell therapeutics. Here, we show that mesenchymal stromal cells …
optimize the efficacy of cell therapeutics. Here, we show that mesenchymal stromal cells …