The coronavirus pandemic (SARS-CoV-2): New problems demand new solutions, the alternative of mesenchymal (stem) stromal cells

N Eiro, JR Cabrera, M Fraile, L Costa… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal (stem) stromal cells (MSC) can be a therapeutic alternative for COVID-19
considering their anti-inflammatory, regenerative, angiogenic, and even antimicrobial …

The therapeutic potential of mesenchymal stromal cells in the treatment of chemotherapy-induced tissue damage

A Rühle, R Lopez Perez, B Zou, AL Grosu… - Stem cell reviews and …, 2019 - Springer
Chemotherapy constitutes one of the key treatment modalities for solid and hematological
malignancies. Albeit being an effective treatment, chemotherapy application is often limited …

Harnessing the ECM microenvironment to ameliorate mesenchymal stromal cell-based therapy in chronic lung diseases

L Elowsson Rendin, A Löfdahl, M Kadefors… - Frontiers in …, 2021 - frontiersin.org
It is known that the cell environment such as biomechanical properties and extracellular
matrix (ECM) composition dictate cell behaviour including migration, proliferation, and …

P311 promotes lung fibrosis via stimulation of transforming growth factor-β1,-β2, and-β3 translation

FF Duan, G Barron, A Meliton, GM Mutlu… - American Journal of …, 2019 - atsjournals.org
Interstitial lung fibrosis, a frequently idiopathic and fatal disease, has been linked to the
increased expression of profibrotic transforming growth factor (TGF)-βs. P311 is an RNA …

Alveolar type II cells or mesenchymal stem cells: comparison of two different cell therapies for the treatment of acute lung injury in rats

R Guillamat-Prats, M Camprubí-Rimblas, F Puig… - Cells, 2020 - mdpi.com
The use of cell therapies has recently increased for the treatment of pulmonary diseases.
Mesenchymal stem/stromal cells (MSCs) and alveolar type II cells (ATII) are the main cell …

Mesenchymal stromal cell therapy for chronic lung diseases: Experimental and clinical evidence

MM Melo, FF Cruz, PRM Rocco - Expert Review of Respiratory …, 2023 - Taylor & Francis
Introduction Cell therapy has emerged as an alternative option for chronic lung diseases
with the highest rates of morbidity and mortality rates worldwide. Areas covered This review …

Material-driven immunomodulation and ECM remodeling reverse pulmonary fibrosis by local delivery of stem cell-laden microcapsules

Y Zhang, Y Zhao, C An, Y Guo, Y Ma, F Shao, Y Zhang… - Biomaterials, 2025 - Elsevier
Recent progress in stem cell therapy has demonstrated the therapeutic potential of
intravenous stem cell infusions for treating the life-threatening lung disease of pulmonary …

Lights and shadows in the use of mesenchymal stem cells in lung inflammation, a poorly investigated topic in cystic fibrosis

A Caretti, V Peli, M Colombo, A Zulueta - Cells, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent non-hematopoietic stem cells residing in
many tissues, including the lung. MSCs have long been regarded as a promising tool for cell …

Paving the road for mesenchymal stem cell-derived exosome therapy in bronchopulmonary dysplasia and pulmonary hypertension

V Yeung, GR Willis, E Taglauer, SA Mitsialis… - Stem Cell-Based …, 2019 - Springer
Bronchopulmonary dysplasia (BPD) is a chronic neonatal lung disease characterized by
inflammation and arrest of alveolarization. Its common sequela, pulmonary hypertension …

[PDF][PDF] Extrapolation of animal research data to humans: an analysis of the evidence

R Ram - Animal Experimentation: Working towards a paradigm …, 2019 - library.oapen.org
The ethical arguments against animal experimentation remain ever-strong. In addition, the
scientific case against the use of animals in research grows more compelling, with …