[HTML][HTML] Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …
[HTML][HTML] HMGB1-mediated neuroinflammatory responses in brain injuries: potential mechanisms and therapeutic opportunities
Brain injuries are devastating conditions, representing a global cause of mortality and
morbidity, with no effective treatment to date. Increased evidence supports the role of …
morbidity, with no effective treatment to date. Increased evidence supports the role of …
Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury
Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Preventative
measures reduce injury incidence and/or severity, yet one-third of hospitalized patients with …
measures reduce injury incidence and/or severity, yet one-third of hospitalized patients with …
[HTML][HTML] White matter damage after traumatic brain injury: a role for damage associated molecular patterns
Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …
[HTML][HTML] Role of damage associated molecular pattern molecules (DAMPs) in aneurysmal subarachnoid hemorrhage (aSAH)
SR Chaudhry, A Hafez, B Rezai Jahromi… - International journal of …, 2018 - mdpi.com
Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes,
but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical …
but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical …
Subarachnoid hemorrhage induces gliosis and increased expression of the pro-inflammatory cytokine high mobility group box 1 protein
Subarachnoid hemorrhage (SAH) following cerebral aneurysm rupture is associated with
high rates of morbidity and mortality. Surviving SAH patients often suffer from neurological …
high rates of morbidity and mortality. Surviving SAH patients often suffer from neurological …
[HTML][HTML] Clinical potential of immunotherapies in Subarachnoid Hemorrhage Treatment: mechanistic dissection of Innate and Adaptive Immune responses
A Zhang, Y Liu, X Wang, H Xu, C Fang, L Yuan… - Aging and …, 2023 - ncbi.nlm.nih.gov
Subarachnoid hemorrhage (SAH), classified as a medical emergency, is a devastating and
severe subtype of stroke. SAH induces an immune response, which further triggers brain …
severe subtype of stroke. SAH induces an immune response, which further triggers brain …
Plasma high-mobility group box 1 levels and prediction of outcome in patients with traumatic brain injury
KY Wang, GF Yu, ZY Zhang, Q Huang, XQ Dong - Clinica chimica acta, 2012 - Elsevier
BACKGROUND: High-mobility group box 1 (HMGB1), a marker of inflammation, has been
associated with poor outcome of critical illness. The present study was undertaken to …
associated with poor outcome of critical illness. The present study was undertaken to …
Cerebral vasospasm
CD Baggott, B Aagaard-Kienitz - Neurosurgery Clinics, 2014 - neurosurgery.theclinics.com
Vasospasm is defined as focal or diffuse temporarily narrowed vessel caliber due to
contraction of smooth muscle in the wall of arteries as detected by angiography or imaging …
contraction of smooth muscle in the wall of arteries as detected by angiography or imaging …
Activation of myeloid TLR4 mediates T lymphocyte polarization after traumatic brain injury
Traumatic brain injury (TBI) is a major public health issue, producing significant patient
mortality and poor long-term outcomes. Increasing evidence suggests an important, yet …
mortality and poor long-term outcomes. Increasing evidence suggests an important, yet …