[HTML][HTML] Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

[HTML][HTML] HMGB1-mediated neuroinflammatory responses in brain injuries: potential mechanisms and therapeutic opportunities

YN Paudel, E Angelopoulou, C Piperi, I Othman… - International Journal of …, 2020 - mdpi.com
Brain injuries are devastating conditions, representing a global cause of mortality and
morbidity, with no effective treatment to date. Increased evidence supports the role of …

Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury

K Vaibhav, M Braun, K Alverson, H Khodadadi… - Science …, 2020 - science.org
Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Preventative
measures reduce injury incidence and/or severity, yet one-third of hospitalized patients with …

[HTML][HTML] White matter damage after traumatic brain injury: a role for damage associated molecular patterns

M Braun, K Vaibhav, NM Saad, S Fatima… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …

[HTML][HTML] Role of damage associated molecular pattern molecules (DAMPs) in aneurysmal subarachnoid hemorrhage (aSAH)

SR Chaudhry, A Hafez, B Rezai Jahromi… - International journal of …, 2018 - mdpi.com
Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes,
but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical …

Subarachnoid hemorrhage induces gliosis and increased expression of the pro-inflammatory cytokine high mobility group box 1 protein

K Murakami, M Koide, TM Dumont, SR Russell… - Translational stroke …, 2011 - Springer
Subarachnoid hemorrhage (SAH) following cerebral aneurysm rupture is associated with
high rates of morbidity and mortality. Surviving SAH patients often suffer from neurological …

[HTML][HTML] Clinical potential of immunotherapies in Subarachnoid Hemorrhage Treatment: mechanistic dissection of Innate and Adaptive Immune responses

A Zhang, Y Liu, X Wang, H Xu, C Fang, L Yuan… - Aging and …, 2023 - ncbi.nlm.nih.gov
Subarachnoid hemorrhage (SAH), classified as a medical emergency, is a devastating and
severe subtype of stroke. SAH induces an immune response, which further triggers brain …

Plasma high-mobility group box 1 levels and prediction of outcome in patients with traumatic brain injury

KY Wang, GF Yu, ZY Zhang, Q Huang, XQ Dong - Clinica chimica acta, 2012 - Elsevier
BACKGROUND: High-mobility group box 1 (HMGB1), a marker of inflammation, has been
associated with poor outcome of critical illness. The present study was undertaken to …

Cerebral vasospasm

CD Baggott, B Aagaard-Kienitz - Neurosurgery Clinics, 2014 - neurosurgery.theclinics.com
Vasospasm is defined as focal or diffuse temporarily narrowed vessel caliber due to
contraction of smooth muscle in the wall of arteries as detected by angiography or imaging …

Activation of myeloid TLR4 mediates T lymphocyte polarization after traumatic brain injury

M Braun, K Vaibhav, N Saad, S Fatima… - The Journal of …, 2017 - journals.aai.org
Traumatic brain injury (TBI) is a major public health issue, producing significant patient
mortality and poor long-term outcomes. Increasing evidence suggests an important, yet …