Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …

Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

An elevated bone microenvironmental reactive oxygen species (ROS) level is a hallmark of
osteoporosis that often leads to the dysfunction of bone-related mesenchymal stem cells …

Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and
immune systems), which preserve the organism's health. We propose that the age-related …

The tumor microenvironment (TME) is a major contributor to cancer malignancy including
development of therapeutic resistance, a process mediated in part through intercellular …

Older age and underlying conditions such as diabetes/obesity or immunosuppression are
leading host risk factors for developing severe complications from COVID‐19 infection. The …

Aging is a natural but relentless process of physiological decline, leading to physical frailty,
reduced ability to respond to physical stresses (resilience) and, ultimately, organismal death …