Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype
Y Liang, C Pan, T Yin, L Wang, X Gao… - Advanced …, 2024 - Wiley Online Library
The essential branched‐chain amino acids (BCAAs) leucine, isoleucine, and valine play
critical roles in protein synthesis and energy metabolism. Despite their widespread use as …
critical roles in protein synthesis and energy metabolism. Despite their widespread use as …
[HTML][HTML] Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy
B Jiang, W Zhang, X Zhang, Y Sun - Seminars in Cancer Biology, 2024 - Elsevier
Cancer is daunting pathology with remarkable breadth and scope, spanning genetics,
epigenetics, proteomics, metalobomics and cell biology. Cellular senescence represents a …
epigenetics, proteomics, metalobomics and cell biology. Cellular senescence represents a …
Drugs with senolytic activity: Prospects and possible limitations
GV Morgunova, AN Khokhlov - Moscow University Biological Sciences …, 2023 - Springer
The search for and testing of drugs with senolytic activity is a new direction in gerontology.
The increasing number of “senescent” cells with age contributes to the development of age …
The increasing number of “senescent” cells with age contributes to the development of age …
Downregulation of Krüppel‐like factor 14 accelerated cellular senescence and aging
Y Hou, Q Song, Y Wang, J Liu, Y Cui, X Zhang… - Aging …, 2023 - Wiley Online Library
Aging has been considered as a risk factor in many diseases, thus, comprehensively
understanding the cellular and molecular mechanisms of delayed aging is important. Here …
understanding the cellular and molecular mechanisms of delayed aging is important. Here …
Aging hallmarks and anti-aging strategies: a landscape of research advancement
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell
damage. Continual functional decline in the intrinsic ability of living organisms to accurately …
damage. Continual functional decline in the intrinsic ability of living organisms to accurately …
Oral senescence: from molecular biology to clinical research
EK Parkinson, SS Prime - Frontiers in Dental Medicine, 2022 - frontiersin.org
Cellular senescence is an irreversible cell cycle arrest occurring following multiple rounds of
cell division (replicative senescence) or in response to cellular stresses such as ionizing …
cell division (replicative senescence) or in response to cellular stresses such as ionizing …
Deciphering the role of rapamycin in modulating decidual senescence: implications for decidual remodeling and implantation failure
R Kendirci-Katirci, L Sati, C Celik-Ozenci - Journal of Assisted …, 2024 - Springer
Purpose Physiological decidual senescence promotes embryo implantation, whereas
pathological decidual senescence causes many pregnancy pathologies. The aim of this …
pathological decidual senescence causes many pregnancy pathologies. The aim of this …
Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice
SK Mun, CJ Jang, S Jo, SH Park, HB Sim… - Animal Cells and …, 2024 - Taylor & Francis
Preventing disease and maintaining the health of the elderly are crucial goals for an aging
population, with obesity and immune function restoration being of paramount importance …
population, with obesity and immune function restoration being of paramount importance …
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6
X Wang, X Li, J Zhou, Z Lei, X Yang - Chemico-Biological Interactions, 2024 - Elsevier
Osteoarthritis (OA) is the most common type of arthritis and is an age-related joint disease
that is particularly prevalent in subjects over 65 years old. The chronic rise of senescent cells …
that is particularly prevalent in subjects over 65 years old. The chronic rise of senescent cells …
[HTML][HTML] Senescence-related genes define prognosis, immune contexture, and pharmacological response in gastric cancer
X Shen, M Wang, W Chen, Y Xu, Q Zhou, T Zhu… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
As one of the prevalent tumors worldwide, gastric cancer (GC) has obtained sufficient
attention in its clinical management and prognostic stratification. Senescence-related genes …
attention in its clinical management and prognostic stratification. Senescence-related genes …