The essential branched‐chain amino acids (BCAAs) leucine, isoleucine, and valine play
critical roles in protein synthesis and energy metabolism. Despite their widespread use as …

Cancer is daunting pathology with remarkable breadth and scope, spanning genetics,
epigenetics, proteomics, metalobomics and cell biology. Cellular senescence represents a …

The search for and testing of drugs with senolytic activity is a new direction in gerontology.
The increasing number of “senescent” cells with age contributes to the development of age …

Aging has been considered as a risk factor in many diseases, thus, comprehensively
understanding the cellular and molecular mechanisms of delayed aging is important. Here …

Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell
damage. Continual functional decline in the intrinsic ability of living organisms to accurately …

Cellular senescence is an irreversible cell cycle arrest occurring following multiple rounds of
cell division (replicative senescence) or in response to cellular stresses such as ionizing …

Purpose Physiological decidual senescence promotes embryo implantation, whereas
pathological decidual senescence causes many pregnancy pathologies. The aim of this …

Preventing disease and maintaining the health of the elderly are crucial goals for an aging
population, with obesity and immune function restoration being of paramount importance …

Osteoarthritis (OA) is the most common type of arthritis and is an age-related joint disease
that is particularly prevalent in subjects over 65 years old. The chronic rise of senescent cells …

As one of the prevalent tumors worldwide, gastric cancer (GC) has obtained sufficient
attention in its clinical management and prognostic stratification. Senescence-related genes …