Chronic kidney disease (CKD) is defined by a low glomerular filtration rate or high
albuminuria, and affects 15–20% of adults globally. CKD increases the risk of various …

Stroke is the second leading cause of death and the third leading cause of disability
worldwide and its burden is increasing rapidly in low-income and middle-income countries …

Background Whether chlorthalidone is superior to hydrochlorothiazide for preventing major
adverse cardiovascular events in patients with hypertension is unclear. Methods In a …

A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

There is strong evidence that sex chromosomes and sex hormones influence blood
pressure (BP) regulation, distribution of cardiovascular (CV) risk factors and co-morbidities …

High systolic blood pressure (SBP) is a major risk factor for ischemic heart disease (IHD), the
leading cause of death worldwide. Using data from published observational studies and …

Background Resistant hypertension is associated with increased cardiovascular risk. The
endothelin pathway has been implicated in the pathogenesis of hypertension, but it is …

Hypertension is the leading modifiable cause of premature death and hence one of the
global targets of World Health Organization for prevention. Hypertension also affects the …

Importance Two initial sham-controlled trials demonstrated that ultrasound renal denervation
decreases blood pressure (BP) in patients with mild to moderate hypertension and …