Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases

M Sharifi-Rad, NV Anil Kumar, P Zucca… - Frontiers in …, 2020 - frontiersin.org
Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as
cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term …

Oxidative stress, plant natural antioxidants, and obesity

I Pérez-Torres, V Castrejón-Téllez, ME Soto… - International journal of …, 2021 - mdpi.com
Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors of
mitochondrial activity, modifying the concentration of inflammation mediators associated with …

Two faces of vitamin C—antioxidative and pro-oxidative agent

J Kaźmierczak-Barańska, K Boguszewska… - Nutrients, 2020 - mdpi.com
Vitamin C has been known for decades. It is common in everyday use as an element of the
diet, supplementation, and a preservative. For years, research has been conducted to …

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

V Rani, G Deep, RK Singh, K Palle, UCS Yadav - Life sciences, 2016 - Elsevier
Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes
and cardiovascular complications together constitute metabolic syndrome. The …

Nutrients, foods, and colorectal cancer prevention

M Song, WS Garrett, AT Chan - Gastroenterology, 2015 - Elsevier
Diet has an important role in the development of colorectal cancer. In the past few decades,
findings from extensive epidemiologic and experimental investigations have linked …

Ascorbic acid: chemistry, biology and the treatment of cancer

J Du, JJ Cullen, GR Buettner - … et Biophysica Acta (BBA)-Reviews on …, 2012 - Elsevier
Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …

Tomato as a source of carotenoids and polyphenols targeted to cancer prevention

R Martí, S Roselló, J Cebolla-Cornejo - Cancers, 2016 - mdpi.com
A diet rich in vegetables has been associated with a reduced risk of many diseases related
to aging and modern lifestyle. Over the past several decades, many researches have …

Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS)

M Ristow, K Schmeisser - Dose-response, 2014 - journals.sagepub.com
Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

Obesity-associated oxidative stress: strategies finalized to improve redox state

I Savini, MV Catani, D Evangelista, V Gasperi… - International journal of …, 2013 - mdpi.com
Obesity represents a major risk factor for a plethora of severe diseases, including diabetes,
cardiovascular disease, non-alcoholic fatty liver disease, and cancer. It is often …

Exogenous antioxidants—Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses

J Bouayed, T Bohn - Oxidative medicine and cellular longevity, 2010 - hindawi.com
The balance between oxidation and antioxidation is believed to be critical in maintaining
healthy biological systems. Under physiological conditions, the human antioxidative defense …