Endometriosis is a chronic systemic disease: clinical challenges and novel innovations

HS Taylor, AM Kotlyar, VA Flores - The Lancet, 2021 - thelancet.com
Endometriosis is a common disease affecting 5–10% of women of reproductive age globally.
However, despite its prevalence, diagnosis is typically delayed by years, misdiagnosis is …

[HTML][HTML] Role of medical therapy in the management of uterine adenomyosis

S Vannuccini, S Luisi, C Tosti, F Sorbi, F Petraglia - Fertility and sterility, 2018 - Elsevier
Adenomyosis is a benign uterine condition affecting women at various ages with different
symptoms. The management of these patients is still controversial. Few clinical studies …

Uterine fibroid management: from the present to the future

J Donnez, MM Dolmans - Human reproduction update, 2016 - academic.oup.com
Uterine fibroids (also known as leiomyomas or myomas) are the most common form of
benign uterine tumors. Clinical presentations include abnormal bleeding, pelvic masses …

Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure

FM Reis, LM Coutinho, S Vannuccini… - Human …, 2020 - academic.oup.com
BACKGROUND Despite intense research, it remains intriguing why hormonal therapies in
general and progestins in particular sometimes fail in endometriosis. OBJECTIVE AND …

Can endometriosis-related oxidative stress pave the way for new treatment targets?

L Cacciottola, J Donnez, MM Dolmans - International journal of molecular …, 2021 - mdpi.com
Endometriosis is a disease of reproductive age characterized by chronic pelvic pain and
infertility. Its pathogenesis is complex and still partially unexplained. However, there is …

Progesterone synthesis in the nervous system: implications for myelination and myelin repair

M Schumacher, R Hussain, N Gago… - Frontiers in …, 2012 - frontiersin.org
Progesterone is well known as a female reproductive hormone and in particular for its role in
uterine receptivity, implantation, and the maintenance of pregnancy. However …

Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications

MB Moravek, P Yin, M Ono, JS Coon V… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Uterine leiomyoma is the most common benign tumor in women and is
thought to arise from the clonal expansion of a single myometrial smooth muscle cell …

子宫肌瘤发病机制研究进展

陈庆云, 张小燕 - 中国实用妇科与产科杂志, 2012 - cqvip.com
子宫肌瘤(uterinemyoma), 亦称子宫平滑肌瘤(leiomyoma), 或子宫纤维瘤(fibroid),
是最常见的女性生殖系统良性肿瘤. 它可以引起子宫异常出血, 盆腔压迫症状 …

Selective progesterone receptor modulators—mechanisms and therapeutic utility

MS Islam, S Afrin, SI Jones, J Segars - Endocrine Reviews, 2020 - academic.oup.com
Selective progesterone receptor modulators (SPRMs) are a new class of compounds
developed to target the progesterone receptor (PR) with a mix of agonist and antagonist …

A comprehensive review of the pharmacologic management of uterine leiomyoma

TD Lewis, M Malik, J Britten… - BioMed research …, 2018 - Wiley Online Library
Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting
up to 80% of women by 50 years of age. It is well established that these tumors are the …