Drugs for insomnia beyond benzodiazepines: pharmacology, clinical applications, and discovery

T Atkin, S Comai, G Gobbi - Pharmacological reviews, 2018 - ASPET
Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and
zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have …

The key role of insomnia and sleep loss in the dysregulation of multiple systems involved in mood disorders: A proposed model

L Palagini, CH Bastien, D Marazziti… - Journal of sleep …, 2019 - Wiley Online Library
Mood disorders are amongst the most prevalent and severe disorders worldwide, with a
tendency to be recurrent and disabling. Although multiple mechanisms have been …

Benzodiazepines and related drugs as a risk factor in Alzheimer's disease dementia

M Ettcheto, J Olloquequi, E Sanchez-Lopez… - Frontiers in aging …, 2020 - frontiersin.org
Benzodiazepines (BZDs) and Z-drugs are compounds widely prescribed in medical practice
due to their anxiolytic, hypnotic, and muscle relaxant properties. Yet, their chronic use is …

Role of Ascaridole and p-Cymene in the Sleep-Promoting Effects of Dysphania ambrosioides Essential Oil via the GABAergic System in a ddY Mouse Inhalation …

G Dougnon, M Ito - Journal of Natural Products, 2020 - ACS Publications
The essential oil obtained from Dysphania ambrosioides leaves (DAEO) has antifungal,
antioxidant, and antimicrobial properties. This study investigated DAEO's chemical …

Impact of sleep disorders and other factors on the quality of life in general population: a cross-sectional study

S Hallit, A Hajj, H Sacre, G Al Karaki… - The Journal of …, 2019 - journals.lww.com
The study objective was to assess if insomnia, along with other factors, can impact the
physical and mental quality of life (QOL) of the Lebanese general population. This cross …

Effect of suvorexant on event-related oscillations and EEG sleep in rats exposed to chronic intermittent ethanol vapor and protracted withdrawal

M Sanchez-Alavez, J Benedict, DN Wills, CL Ehlers - Sleep, 2019 - academic.oup.com
Abstract Study Objectives Insomnia is a prominent complaint in patients with alcohol use
disorders (AUD). However, despite the importance of sleep in the maintenance of sobriety …

Cost-effectiveness analysis of lemborexant for treating insomnia in Japan: a model-based projection, incorporating the risk of falls, motor vehicle collisions, and …

S Ikeda, MK Azuma, K Fujimoto, H Shibahara… - Psychological …, 2022 - cambridge.org
BackgroundLemborexant has demonstrated statistically significant improvements in sleep
onset and sleep maintenance compared with placebo and zolpidem tartrate extended …

Factors associated with insomnia among truck drivers in Japan

T Miyachi, K Nomura, S Minamizono… - Nature and science of …, 2021 - Taylor & Francis
Purpose Truck drivers with insomnia are at a high risk of traffic accidents. We aimed to
investigate the prevalence of insomnia and identify its associated factors among truck …

The intervention strategies of sleep quality among college students: A quantitative review

F Wang - College Student Journal, 2021 - ingentaconnect.com
Over the last decade, sleep quality becomes serious issue in academic research. There was
an increasing number of interventions conducted to improve sleep quality. Objective: This …

Sleep disorders

A Lawson, R Parmar, EP Sloan - Perinatal Psychopharmacology, 2019 - Springer
The physiological and psychological alterations of pregnancy, childbirth, and the postpartum
may significantly impact a woman's sleep. Sleep disorders during this time are common …