Modulation of angiotensin II signaling following exercise training in heart failure

IH Zucker, HD Schultz, KP Patel… - American Journal of …, 2015 - journals.physiology.org
Sympathetic activation is a consistent finding in the chronic heart failure (CHF) state. Current
therapy for CHF targets the renin-angiotensin II (ANG II) and adrenergic systems …

Increased cardiac sympathetic nerve activity in ovine heart failure is reduced by lesion of the area postrema, but not lamina terminalis

Y Abukar, R Ramchandra, SG Hood… - Basic research in …, 2018 - Springer
Increased cardiac sympathetic nerve activity (CSNA) is a key feature of heart failure (HF)
and is associated with poor outcome. There is evidence that central angiotensinergic …

Cardiac sympathoexcitation in heart failure

CN May, ST Yao, LC Booth, R Ramchandra - Autonomic Neuroscience, 2013 - Elsevier
Heart failure (HF) is a serious debilitating condition with poor survival rates and an
increasing level of prevalence. The excessive sympatho-excitation that is a hallmark of heart …

Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure

R Ramchandra, SG Hood, AMD Watson, AM Allen… - …, 2012 - Am Heart Assoc
In heart failure (HF), cardiac sympathetic nerve activity (SNA; CSNA) is increased, which has
detrimental effects on the heart and promotes arrhythmias and sudden death. There is …

Neurohumoral interactions contributing to renal vasoconstriction and decreased renal blood flow in heart failure

R Ramchandra, DT Xing, M Matear… - American Journal …, 2019 - journals.physiology.org
In heart failure (HF), increases in renal sympathetic nerve activity (RSNA), renal
norepinephrine spillover, and renin release cause renal vasoconstriction, which may …

Angiotensin-(1–7) in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats

Y Han, HJ Sun, P Li, Q Gao, Y Zhou, F Zhang, XY Gao… - PLoS …, 2012 - journals.plos.org
Background Excessive sympathetic activity contributes to the pathogenesis and progression
of hypertension. Enhanced cardiac sympathetic afferent reflex (CSAR) is involved in …

Short-term effects of catheter-based renal denervation on cardiac sympathetic drive and cardiac baroreflex function in heart failure

LC Booth, MP Schlaich, EE Nishi, ST Yao, J Xu… - International Journal of …, 2015 - Elsevier
Objectives Sympathetic drive, especially to the heart, is elevated in heart failure and is
strongly associated with poor outcome. The mechanisms causing the increased sympathetic …

Sympathoactivation and rho-kinase-dependent baroreflex function in experimental renovascular hypertension with reduced kidney mass

RU Pliquett, S Benkhoff, O Jung, RP Brandes - BMC physiology, 2014 - Springer
Background Dysregulation of the autonomic nervous system is frequent in subjects with
cardiovascular disease. The contribution of different forms of renovascular hypertension and …

血管紧张素Ⅱ 受体拮抗剂在治疗充血性心力衰竭的研究进展

郭明, 杨丽霞, 周晓斌 - 中国循证心血管医学杂志, 2013 - cqvip.com
充血性心力衰竭(congestive heart Failure, CHF, 心衰), 是各种心脏疾病发展的终末阶段,
严重影响着患者的预后和生存质量. 随着循证医学证据的不断涌现, 临床上对CHF …

Intrathecal administration of losartan reduces directly recorded cardiac sympathetic nerve activity in ovine heart failure

S Leversha, AM Allen, CN May, R Ramchandra - Hypertension, 2019 - Am Heart Assoc
Early and preferential activation of cardiac sympathetic nerve activity (CSNA) is one of the
strongest prognostic markers of heart failure (HF) in patients. Our previous studies have …