Modulation of angiotensin II signaling following exercise training in heart failure
IH Zucker, HD Schultz, KP Patel… - American Journal of …, 2015 - journals.physiology.org
Sympathetic activation is a consistent finding in the chronic heart failure (CHF) state. Current
therapy for CHF targets the renin-angiotensin II (ANG II) and adrenergic systems …
therapy for CHF targets the renin-angiotensin II (ANG II) and adrenergic systems …
Increased cardiac sympathetic nerve activity in ovine heart failure is reduced by lesion of the area postrema, but not lamina terminalis
Y Abukar, R Ramchandra, SG Hood… - Basic research in …, 2018 - Springer
Increased cardiac sympathetic nerve activity (CSNA) is a key feature of heart failure (HF)
and is associated with poor outcome. There is evidence that central angiotensinergic …
and is associated with poor outcome. There is evidence that central angiotensinergic …
Cardiac sympathoexcitation in heart failure
Heart failure (HF) is a serious debilitating condition with poor survival rates and an
increasing level of prevalence. The excessive sympatho-excitation that is a hallmark of heart …
increasing level of prevalence. The excessive sympatho-excitation that is a hallmark of heart …
Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure
R Ramchandra, SG Hood, AMD Watson, AM Allen… - …, 2012 - Am Heart Assoc
In heart failure (HF), cardiac sympathetic nerve activity (SNA; CSNA) is increased, which has
detrimental effects on the heart and promotes arrhythmias and sudden death. There is …
detrimental effects on the heart and promotes arrhythmias and sudden death. There is …
Neurohumoral interactions contributing to renal vasoconstriction and decreased renal blood flow in heart failure
R Ramchandra, DT Xing, M Matear… - American Journal …, 2019 - journals.physiology.org
In heart failure (HF), increases in renal sympathetic nerve activity (RSNA), renal
norepinephrine spillover, and renin release cause renal vasoconstriction, which may …
norepinephrine spillover, and renin release cause renal vasoconstriction, which may …
Angiotensin-(1–7) in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats
Y Han, HJ Sun, P Li, Q Gao, Y Zhou, F Zhang, XY Gao… - PLoS …, 2012 - journals.plos.org
Background Excessive sympathetic activity contributes to the pathogenesis and progression
of hypertension. Enhanced cardiac sympathetic afferent reflex (CSAR) is involved in …
of hypertension. Enhanced cardiac sympathetic afferent reflex (CSAR) is involved in …
Short-term effects of catheter-based renal denervation on cardiac sympathetic drive and cardiac baroreflex function in heart failure
Objectives Sympathetic drive, especially to the heart, is elevated in heart failure and is
strongly associated with poor outcome. The mechanisms causing the increased sympathetic …
strongly associated with poor outcome. The mechanisms causing the increased sympathetic …
Sympathoactivation and rho-kinase-dependent baroreflex function in experimental renovascular hypertension with reduced kidney mass
RU Pliquett, S Benkhoff, O Jung, RP Brandes - BMC physiology, 2014 - Springer
Background Dysregulation of the autonomic nervous system is frequent in subjects with
cardiovascular disease. The contribution of different forms of renovascular hypertension and …
cardiovascular disease. The contribution of different forms of renovascular hypertension and …
血管紧张素Ⅱ 受体拮抗剂在治疗充血性心力衰竭的研究进展
郭明, 杨丽霞, 周晓斌 - 中国循证心血管医学杂志, 2013 - cqvip.com
充血性心力衰竭(congestive heart Failure, CHF, 心衰), 是各种心脏疾病发展的终末阶段,
严重影响着患者的预后和生存质量. 随着循证医学证据的不断涌现, 临床上对CHF …
严重影响着患者的预后和生存质量. 随着循证医学证据的不断涌现, 临床上对CHF …
Intrathecal administration of losartan reduces directly recorded cardiac sympathetic nerve activity in ovine heart failure
S Leversha, AM Allen, CN May, R Ramchandra - Hypertension, 2019 - Am Heart Assoc
Early and preferential activation of cardiac sympathetic nerve activity (CSNA) is one of the
strongest prognostic markers of heart failure (HF) in patients. Our previous studies have …
strongest prognostic markers of heart failure (HF) in patients. Our previous studies have …