Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: a review

MS Mulani, EE Kamble, SN Kumkar… - Frontiers in …, 2019 - frontiersin.org
The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance
and virulence: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae …

Rationalizing antimicrobial therapy in the ICU: a narrative review

JF Timsit, M Bassetti, O Cremer, G Daikos… - Intensive care …, 2019 - Springer
The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

A novel antibiotic class targeting the lipopolysaccharide transporter

C Zampaloni, P Mattei, K Bleicher, L Winther, C Thäte… - Nature, 2024 - nature.com
Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global
pathogen with limited treatment options. No new antibiotic chemical class with activity …

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

CO Vrancianu, I Gheorghe, IB Czobor, MC Chifiriuc - Microorganisms, 2020 - mdpi.com
Antibiotic resistance is one of the biggest challenges for the clinical sector and industry,
environment and societal development. One of the most important pathogens responsible …

Pandrug-resistant Gram-negative bacteria: a systematic review of current epidemiology, prognosis and treatment options

S Karakonstantis, EI Kritsotakis… - Journal of Antimicrobial …, 2020 - academic.oup.com
Background The literature on the epidemiology, mortality and treatment of pandrug-resistant
(PDR) Gram-negative bacteria (GNB) is scarce, scattered and controversial. Objectives To …

Acinetobacter baumannii in the critically ill: complex infections get complicated

I Cavallo, A Oliva, R Pages, F Sivori, M Truglio… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is increasingly associated with various epidemics, representing a
serious concern due to the broad level of antimicrobial resistance and clinical …

Antimicrobial Susceptibility of Acinetobacter calcoaceticus–Acinetobacter baumannii Complex and Stenotrophomonas maltophilia Clinical Isolates: Results From the …

AC Gales, H Seifert, D Gur… - Open forum …, 2019 - academic.oup.com
Background Acinetobacter calcoaceticus–A. baumannii (Acb) complex and
Stenotrophomonas maltophilia represent frequent causes of hospital-acquired infections …

Acinetobacter baumannii

C Whiteway, A Breine, C Philippe… - Trends in microbiology, 2022 - cell.com
Acinetobacter baumannii is a ubiquitous, Gram-negative, nonflagellated coccobacillus
bacterium commonly isolated from the environment. In human medicine, this opportunistic …

Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin

E Michalczyk, K Hommernick, I Behroz, M Kulike… - Nature …, 2023 - nature.com
The peptide antibiotic albicidin is a DNA topoisomerase inhibitor with low-nanomolar
bactericidal activity towards fluoroquinolone-resistant Gram-negative pathogens. However …

Mapping Global Prevalence of Acinetobacter baumannii and Recent Vaccine Development to Tackle It

C Ma, S McClean - Vaccines, 2021 - mdpi.com
Acinetobacter baumannii is a leading cause of nosocomial infections that severely threaten
public health. The formidable adaptability and resistance of this opportunistic pathogen have …