Natural selection and infectious disease in human populations
EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …
genetic variation in modern populations, and this has important implications for the growing …
A genomic perspective on HLA evolution
Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
[HTML][HTML] Human demographic history impacts genetic risk prediction across diverse populations
The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …
Europeans, and their transferability to other populations is dependent on many factors (eg …
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …
relatedness and population stratification, can yield an inflated distribution of test statistics in …
Inference of population splits and mixtures from genome-wide allele frequency data
J Pickrell, J Pritchard - Nature Precedings, 2012 - nature.com
Many aspects of the historical relationships between populations in a species are reflected
in genetic data. Inferring these relationships from genetic data, however, remains a …
in genetic data. Inferring these relationships from genetic data, however, remains a …
Fast principal-component analysis reveals convergent evolution of ADH1B in Europe and East Asia
Searching for genetic variants with unusual differentiation between subpopulations is an
established approach for identifying signals of natural selection. However, existing methods …
established approach for identifying signals of natural selection. However, existing methods …
Robust identification of local adaptation from allele frequencies
Comparing allele frequencies among populations that differ in environment has long been a
tool for detecting loci involved in local adaptation. However, such analyses are complicated …
tool for detecting loci involved in local adaptation. However, such analyses are complicated …
Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America
Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-
speaking populations remains largely unexplored. We generated genomic data for 1318 …
speaking populations remains largely unexplored. We generated genomic data for 1318 …
On detecting incomplete soft or hard selective sweeps using haplotype structure
A Ferrer-Admetlla, M Liang… - Molecular biology …, 2014 - academic.oup.com
We present a new haplotype-based statistic (nS L) for detecting both soft and hard sweeps
in population genomic data from a single population. We compare our new method with …
in population genomic data from a single population. We compare our new method with …
Detection of human adaptation during the past 2000 years
Detection of recent natural selection is a challenging problem in population genetics. Here
we introduce the singleton density score (SDS), a method to infer very recent changes in …
we introduce the singleton density score (SDS), a method to infer very recent changes in …