[HTML][HTML] Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …
[HTML][HTML] Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation
A Bonaventura, A Vecchié, L Dagna, F Tangianu… - Inflammation …, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is capable of inducing the
activation of NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) …
activation of NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) …
American College of Rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS–CoV‐2 and hyperinflammation in …
LA Henderson, SW Canna, KG Friedman… - Arthritis & …, 2022 - Wiley Online Library
Objective To provide guidance on the management of Multisystem Inflammatory Syndrome
in Children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …
in Children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …
[HTML][HTML] COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation
Background Recent single-center reports have suggested that community-acquired
bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an …
bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an …
[HTML][HTML] The efficacy and safety of levilimab in severely ill COVID-19 patients not requiring mechanical ventilation: results of a multicenter randomized double-blind …
NV Lomakin, BA Bakirov, DN Protsenko… - Inflammation …, 2021 - Springer
Objective and design The aim of this double-blind, placebo-controlled, phase III CORONA
clinical trial was to evaluate the efficacy and safety of IL-6 receptor inhibitor levilimab (LVL) …
clinical trial was to evaluate the efficacy and safety of IL-6 receptor inhibitor levilimab (LVL) …
[HTML][HTML] An observational study on factors associated with ICU mortality in Covid-19 patients and critical review of the literature
A Lavrentieva, E Kaimakamis, V Voutsas, M Bitzani - Scientific Reports, 2023 - nature.com
The novel pandemic caused by SARS-CoV-2 has been associated with increased burden
on healthcare system. Recognizing the variables that independently predict death in COVID …
on healthcare system. Recognizing the variables that independently predict death in COVID …
[HTML][HTML] Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for …
F Baldi, C Dentone, M Mikulska, D Fenoglio… - Frontiers in …, 2023 - frontiersin.org
COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with
the host immune system and the role of therapy still remains only partly understood. There …
the host immune system and the role of therapy still remains only partly understood. There …
Lymphopenia in sepsis—an acquired immunodeficiency?
S Finfer, B Venkatesh, RS Hotchkiss… - Immunology and Cell …, 2023 - Wiley Online Library
Sepsis is a global health priority, yet effective host‐directed targeted therapies have not
been identified outside of the setting of coronavirus disease 2019 (COVID‐19) …
been identified outside of the setting of coronavirus disease 2019 (COVID‐19) …
[HTML][HTML] Herpes simplex virus 1 (HSV-1) reactivation in critically ill COVID-19 patients: A brief narrative review
DR Giacobbe, S Di Bella, A Lovecchio, L Ball… - Infectious Diseases and …, 2022 - Springer
Systemic or pulmonary reactivations of herpes simplex virus 1 (HSV-1) have been reported
in critically ill patients with COVID-19, posing a dilemma for clinicians in terms of their …
in critically ill patients with COVID-19, posing a dilemma for clinicians in terms of their …
Host response biomarkers for sepsis in the emergency room
O Turgman, M Schinkel, WJ Wiersinga - Annual Update in Intensive Care …, 2023 - Springer
Hundreds of biomarkers for sepsis have been evaluated in clinical and experimental studies
and advocated to be used in the emergency room. They can have diagnostic, prognostic …
and advocated to be used in the emergency room. They can have diagnostic, prognostic …