Biomarkers for diagnosis of neonatal sepsis: a literature review

D Sharma, N Farahbakhsh, S Shastri… - The Journal of Maternal …, 2018 - Taylor & Francis
Sepsis is an important cause of mortality and morbidity in neonatal populations. There has
been constant search of an ideal sepsis biomarker that have high sensitivity, specificity …

[PDF][PDF] Neonatal sepsis

IO Odabasi, A Bulbul - Şişli Etfal Hastanesi Tip Bülteni, 2020 - jag.journalagent.com
Neonatal sepsis is associated with severe morbidity and mortality in the neonatal period.
Clinical manifestations range from subclinical infection to severe local or systemic infection …

Potential biomarkers for effective screening of neonatal sepsis infections: An overview

N Chauhan, S Tiwari, U Jain - Microbial pathogenesis, 2017 - Elsevier
Neonatal sepsis, a clinical disorder developed by bacterial blood stream infections (BSI) in
neonates, is one of the serious global public health problems that must be addressed. More …

Soluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: new clinical and analytical perspectives for two old …

M Mussap, A Noto, M Fravega… - The Journal of Maternal …, 2011 - Taylor & Francis
Several biochemical markers have been proposed over the past years to manage critically ill
newborns with acute inflammation and sepsis. The state of the art in diagnosing and …

[HTML][HTML] The implication of targeting PD-1: PD-L1 pathway in treating sepsis through immunostimulatory and anti-inflammatory pathways

Y Chen, D Guo, C Zhu, S Ren, C Sun, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Sepsis currently remains a major contributor to mortality in the intensive care unit (ICU), with
48.9 million cases reported globally and a mortality rate of 22.5% in 2017, accounting for …

The role of complement system in septic shock

J Charchaflieh, J Wei, G Labaze, YJ Hou… - Journal of …, 2012 - Wiley Online Library
Septic shock is a critical clinical condition with a high mortality rate. A better understanding
of the underlying mechanisms is important to develop effective therapies. Basic and clinical …

[HTML][HTML] Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice

LD McCullough, M Roy-O'Reilly, YJ Lai… - The Journal of …, 2021 - Am Soc Clin Investig
Inter-α inhibitor proteins (IAIPs) are a family of endogenous plasma and extracellular matrix
molecules. IAIPs suppress proinflammatory cytokines, limit excess complement activation …

Biomarkers for neonatal sepsis: recent developments

P Mally, J Xu, KD Hendricks-Muñoz - Research and Reports in …, 2014 - Taylor & Francis
As a leading cause of neonatal morbidity and mortality, neonatal sepsis remains a
significant global health challenge. Despite recent advances in the management of neonatal …

Lipidomics study of sepsis-induced liver and lung injury under anti-HMGB1 intervention

J Huang, Z Wang, X Zhang, Y Gou, J Li… - Journal of Proteome …, 2023 - ACS Publications
Sepsis usually leads to lethal multiorgan dysfunction including acute liver failure (ALF) and
acute lung injury (ALI). This research sought to reveal the lipid alteration of anti-high mobility …

Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: relevance to translational research

H Saminathan, A Charli, J Luo, N Panicker… - European journal of …, 2020 - Elsevier
Systemic inflammation resulting from the release of pro-inflammatory cytokines and the
chronic activation of the innate immune system remains a major cause of morbidity and …