Is amiodarone an underrecognized cause of acute respiratory failure in the ICU?

H Ashrafian, P Davey - Chest, 2001 - Elsevier
Amiodarone is a commonly used anti-arrhythmic agent, withwell-recognized chronic toxicity.
Less well known is amiodarone'spotential to cause acute lung damage, which can be …

Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity

JW Card, WJ Racz, JF Brien, SB Margolin… - Toxicological …, 2003 - academic.oup.com
Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the
antidysrhythmic drug amiodarone (AM). We tested the potential usefulness of pirfenidone …

Role of oxidative stress in amiodarone-induced toxicity

JSM Sarma, H Pei… - Journal of Cardiovascular …, 1997 - journals.sagepub.com
Background: The clinical usefulness of amiodarone for the treatment of cardiac arrhythmias
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …

Aryl radical involvement in amiodarone-induced pulmonary toxicity: investigation of protection by spin-trapping nitrones

AC Nicolescu, JL Comeau, BC Hill, LL Bedard… - Toxicology and applied …, 2007 - Elsevier
Amiodarone (AM), an antidysrrhythmic drug, can produce serious adverse effects, including
potentially fatal AM-induced pulmonary toxicity (AIPT). AM-induced cytotoxicity and …

Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone-and vehicle-treated hamsters

JW Card, RG Leeder, WJ Racz, JF Brien, TM Bray… - Toxicology, 1999 - Elsevier
Amiodarone (AM) is a potent antidysrhythmic agent that is limited in clinical use by its
adverse effects, including potentially life-threatening AM-induced pulmonary toxicity (AIPT) …

Amiodarone-induced disruption of hamster lung and liver mitochondrial function: lack of association with thiobarbituric acid-reactive substance production

JW Card, BR Lalonde, E Rafeiro, AS Tam, WJ Racz… - Toxicology letters, 1998 - Elsevier
Amiodarone (AM) is an efficacious antidysrhythmic agent that is limited clinically by
numerous adverse effects. Of greatest concern is AM-induced pulmonary toxicity (AIPT) due …

Evaluation of reactive oxygen species involvement in amiodarone pulmonary toxicity in vivo and in vitro

RG Leeder, E Rafeiro, JF Brien… - Journal of …, 1996 - Wiley Online Library
Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …

A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the …

MD Taylor, K Van Dyke, LL Bowman, PR Miles… - Toxicology and applied …, 2000 - Elsevier
Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …

Amiodarone-induced pulmonary fibrosis in Fischer 344 rats

PG Reinhart, YL Lai, CG Gairola - Toxicology, 1996 - Elsevier
Amiodarone is a potent antiarrhythmic agent with a number of side-effects, the most serious
being the development of pulmonary toxicity. The purpose of the study was to determine if a …

Pharmaceutical compounds with antioxidant activity

A Bast, GRMM Haenen - Antioxidants and Cardiovascular Disease, 2000 - Springer
In the lay press, antioxidants are often regarded as magic compounds. Antioxidants are
claimed to heal almost every human inconvenience. Chemically, an antioxidant is a …