ABSTRACT A recent Perspective article described the “carbohydrate-insulin model (CIM)” of
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …

The obesity pandemic continues unabated despite a persistent public health campaign to
decrease energy intake (“eat less”) and increase energy expenditure (“move more”). One …

Feeding behaviors depend on intrinsic and extrinsic factors including genetics, food
palatability, and the environment. 1, 2, 3, 4, 5 The gut microbiota is a major environmental …

For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking
and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known …

The lateral hypothalamic area (LHA) integrates homeostatic processes and reward-
motivated behaviors. Here we show that LHA neurons that produce melanin-concentrating …

Recent work has demonstrated the ability of the gut microbiota (GM) to alter the expression
and release of gut peptides that control appetite and regulate energy homeostasis …

The food environment has changed rapidly and dramatically in the last 50 years. While
industrial food processing has increased the safety and stability of the food supply, a rapid …

Norepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system is
targeted by several anti-obesity drugs. To better understand the circuitry underlying …

The intellectual history of energy homeostasis, focusing on food intake and energy storage,
is briefly reviewed. Physiological energetics was founded by Lavoisier, who in the late …

The interaction of exercise with appetite control and energy intake has been widely studied
due to the ability of exercise-related energy expenditure to influence energy and substrate …